DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Argk and Ckb

DIOPT Version :9

Sequence 1:	NP_729446.1	Gene:	Argk / 39041	FlyBaseID:	FBgn0000116	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_036661.3	Gene:	Ckb / 24264	RGDID:	2357	Length:	381	Species:	Rattus norvegicus

Alignment Length:	357	Identity:	156/357 - (43%)
Similarity:	224/357 - (62%)	Gaps:	17/357 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EEGYAKLAASDSKSLLKKYLTKEVFDNLKNKVTPTFKSTLLDVIQSGLEN----HDSGVGIYAPD 277
            |:.:..|::.::.  :.|.||.|::..|:.|.||: ..||.|.||:|::|    :...||..|.|
  Rat    17 EDEFPDLSSHNNH--MAKVLTPELYAELRAKCTPS-GFTLDDAIQTGVDNPGHPYIMTVGAVAGD 78

  Fly   278 AEAYTVFADLFDPIIEDYHGGFKKTDKHPAS-NFGDVSTFGNVDPTNEYVISTRVRCGRSMQGYP 341
            .|:|.||.|||||||||.|||::.:|:|... |..::....::||  .||:|:|||.|||::|:.
  Rat    79 EESYDVFKDLFDPIIEDRHGGYQPSDEHKTDLNPDNLQGGDDLDP--NYVLSSRVRTGRSIRGFC 141

  Fly   342 FNPCLTEAQYKEMESKVSSTLSGLEGELKGKFYPLTGMEKAVQQQLIDDHFLF-KEGDRFLQAAN 405
            ..|..:..:.:.:|......||.|:|:|.|::|.|..|.:|.||||||||||| |.....|.|:.
  Rat   142 LPPHCSRGERRAIEKLAVEALSSLDGDLSGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASG 206

  Fly   406 ACRFWPSGRGIYHNDAKTFLVWCNEEDHLRIISMQQGGDLGQIYKRLVTAVNEIE-----KRVPF 465
            ..|.||..|||:|||.||||||.|||||||:||||:||::.:::.|..|.:.:||     |...|
  Rat   207 MARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKNYEF 271

  Fly   466 SHDDRLGFLTFCPTNLGTTIRASVHIKVPKLASNKAKLEEVAAKYNLQVRGTRGEHTEAEGGVYD 530
            ..:..||::..||:||||.:||.||||:|.|..:: |..||..:..||.|||.|..|.|.|||:|
  Rat   272 MWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKHE-KFSEVLKRLRLQKRGTGGVDTAAVGGVFD 335

  Fly   531 ISNKRRMGLTEFEAVKEMYDGITELIKLEKSL 562
            :||..|:|.:|.|.|:.:.||:..||::|:.|
  Rat   336 VSNADRLGFSEVELVQMVVDGVKLLIEMEQRL 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Argk	NP_729446.1	arginine_kinase_like	215..562	CDD:153079	155/355 (44%)
Ckb	NP_036661.3	creatine_kinase_like	16..373	CDD:153076	156/357 (44%)
Ckb	NP_036661.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..122		6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341348
Domainoid	1	1.000	197	1.000	Domainoid score	I3004
eggNOG	1	0.900	-	-		E1_COG3869
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2802
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287050at33208
OrthoFinder	1	1.000	-	-		FOG0000437
OrthoInspector	1	1.000	-	-		mtm9032
orthoMCL	1	0.900	-	-		OOG6_100675
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X315
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.660