DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Argk and CKM

DIOPT Version :9

Sequence 1:	NP_729446.1	Gene:	Argk / 39041	FlyBaseID:	FBgn0000116	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001815.2	Gene:	CKM / 1158	HGNCID:	1994	Length:	381	Species:	Homo sapiens

Alignment Length:	359	Identity:	158/359 - (44%)
Similarity:	222/359 - (61%)	Gaps:	17/359 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 KLEEGYAKLAASDSKSLLKKYLTKEVFDNLKNKVTPTFKSTLLDVIQSGLEN--HD--SGVGIYA 275
            |.||.|..|  |...:.:.|.||.|::..|::|.||: ..|:.||||:|::|  |.  ..||..|
Human    15 KPEEEYPDL--SKHNNHMAKVLTLELYKKLRDKETPS-GFTVDDVIQTGVDNPGHPFIMTVGCVA 76

  Fly   276 PDAEAYTVFADLFDPIIEDYHGGFKKTDKHPAS-NFGDVSTFGNVDPTNEYVISTRVRCGRSMQG 339
            .|.|:|.||.:||||||.|.|||:|.||||... |..::....::||  .||:|:|||.|||::|
Human    77 GDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDDLDP--NYVLSSRVRTGRSIKG 139

  Fly   340 YPFNPCLTEAQYKEMESKVSSTLSGLEGELKGKFYPLTGMEKAVQQQLIDDHFLF-KEGDRFLQA 403
            |...|..:..:.:.:|......|:.|.||.|||:|||..|.:..||||||||||| |.....|.|
Human   140 YTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLA 204

  Fly   404 ANACRFWPSGRGIYHNDAKTFLVWCNEEDHLRIISMQQGGDLGQIYKRLVTAVNEIE---KRV-- 463
            :...|.||..|||:|||.|:||||.|||||||:|||::||::.::::|....:.:||   |:.
Human   205 SGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGH 269

  Fly   464 PFSHDDRLGFLTFCPTNLGTTIRASVHIKVPKLASNKAKLEEVAAKYNLQVRGTRGEHTEAEGGV 528
            ||..:..||::..||:||||.:|..||:|:..| |...|.||:..:..||.|||.|..|.|.|.|
Human   270 PFMWNQHLGYVLTCPSNLGTGLRGGVHVKLAHL-SKHPKFEEILTRLRLQKRGTGGVDTAAVGSV 333

  Fly   529 YDISNKRRMGLTEFEAVKEMYDGITELIKLEKSL 562
            :|:||..|:|.:|.|.|:.:.||:..::::||.|
Human   334 FDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKL 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Argk	NP_729446.1	arginine_kinase_like	215..562	CDD:153079	157/357 (44%)
CKM	NP_001815.2	creatine_kinase_like	16..373	CDD:153076	157/358 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147547
Domainoid	1	1.000	196	1.000	Domainoid score	I3115
eggNOG	1	0.900	-	-		E1_COG3869
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2904
Isobase	1	0.950	-	0	Normalized mean entropy	S3995
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287050at33208
OrthoFinder	1	1.000	-	-		FOG0000437
OrthoInspector	1	1.000	-	-		mtm8556
orthoMCL	1	0.900	-	-		OOG6_100675
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2592
SonicParanoid	1	1.000	-	-		X315
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.640