DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5144 and CKB

DIOPT Version :9

Sequence 1:	NP_648284.1	Gene:	CG5144 / 39040	FlyBaseID:	FBgn0035957	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001349460.1	Gene:	CKB / 1152	HGNCID:	1991	Length:	405	Species:	Homo sapiens

Alignment Length:	363	Identity:	143/363 - (39%)
Similarity:	212/363 - (58%)	Gaps:	39/363 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LKKHLTKEIFEKLKTKTTPSFNSTLLHCISSGMCN----HDSGVGLYAPDPEAYKVFADLFDPVI 115
            :.|.||.|::.:|:.|:||| ..||...|.:|:.|    :...||..|.|.|:|:||.|||||:|
Human    30 MAKVLTPELYAELRAKSTPS-GFTLDDVIQTGVDNPGHPYIMTVGCVAGDEESYEVFKDLFDPII 93

  Fly   116 EEYHKCFK-----KTDKQP----------ATAFGKGAD----------FENLDPDGHFIVSTRVR 155
            |:.|..:|     |||..|          |...|.|:.          .::|||  ::::|:|||
Human    94 EDRHGGYKPSDEHKTDLNPDNLQVRGCGRAGRAGPGSSGAHSRLASQGGDDLDP--NYVLSSRVR 156

  Fly   156 CGRAVKGYPFNPCLTEADYMELESKICGAVTSLTGEYKGKYMPLTGMDKCIQEQLIEDHYLF-KE 219
            .||:::|:...|..:..:...:|.....|::||.|:..|:|..|..|.:..|:|||:||:|| |.
Human   157 TGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKP 221

  Fly   220 GDRFLASAGASRYWPTGRGIFLNSAKNFLVWCNEEDHIRIISMEKGGDLGKVYDRMVGG---VEA 281
            ....|.::|.:|.||..|||:.|..|.||||.|||||:|:|||:|||::.:|:.|...|   :|.
Human   222 VSPLLLASGMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRFCTGLTQIET 286

  Fly   282 L--GKQLQFNRDERLGFLTFCPTNLGTSIRASVHIKLPNLMCDPDEMKKLADKYRLQIRGTSGEH 344
            |  .|..:|..:..||::..||:||||.:||.|||||||| ...::..::..:.|||.|||.|..
Human   287 LFKSKDYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPNL-GKHEKFSEVLKRLRLQKRGTGGVD 350

  Fly   345 SEAKGGVHDISNQRRMGLTEYEIIKEMHDGIKGLIEAE 382
            :.|.|||.|:||..|:|.:|.|:::.:.||:|.|||.|
Human   351 TAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEME 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5144	NP_648284.1	arginine_kinase_like	40..382	CDD:153079	142/361 (39%)
CKB	NP_001349460.1	creatine_kinase_like	16..397	CDD:153076	143/363 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147542
Domainoid	1	1.000	196	1.000	Domainoid score	I3115
eggNOG	1	0.900	-	-		E1_COG3869
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2904
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58958
OrthoDB	1	1.010	-	-		D287050at33208
OrthoFinder	1	1.000	-	-		FOG0000437
OrthoInspector	1	1.000	-	-		mtm8556
orthoMCL	1	0.900	-	-		OOG6_100675
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X315
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.670