Protein Alignment Doc1 and TBX18

DIOPT Version :9

• Sequence 1: NP_648283.1
• Gene: Doc1 / 39039
• FlyBaseID: FBgn0028789
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_001073977.1
• Gene: TBX18 / 9096
• HGNCID: 11595
• Length: 607
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 144/401 - (35%)
• Similarity: 203/401 - (50%)
• Gaps: 84/401 - (20%)

  Fly    45 QPHMMLPSRPTLPGVEAKLENNDLWQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVLL 109
            :|...||| |..|.|:  |:..:||::||:|||||||||:||||||:|||.:|||:....|.:.:
Human   128 RPGTPLPS-PQAPRVD--LQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAM 189

  Fly   110 EMVPIGDCRYK--FSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLDS 172
            ::||:.:.||:  :..|:|:.||.|:...|.|:|:||||||:|..|..|.:.|:|:|||||.||.
Human   190 DIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDD 254

  Fly   173 SGHIVLASMHKYQPRLHIIR---SSELTQLPWAPQ----QAFVFPETEFVAVTAYQNDRITKLKI 230
            .|||:|.||||||||:|:||   ..:|:.:...|.    :||.||||.|..||||||.:||:|||
Human   255 QGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKI 319

  Fly   231 DNNPFAKGFRESGQSR---------------------------CKRKLNSSGNSTLESEDDG--- 265
            |.||||||||:||::|                           ..::.|:|.::.|:...:|
Human   320 DRNPFAKGFRDSGRNRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNASSSTLLQGTGNGVPA 384

  Fly   266 -----SSVSSCDSPQAKRQRQDF----EQDSTGSVSPAYYGATHPVANPMSPYLRHHLSYGPSGA 321
                 .|.|||.||.       |    ......|::||.|.|.......::.|
Human   385 THPHLLSGSSCSSPA-------FHLGPNTSQLCSLAPADYSACARSGLTLNRY------------ 430

  Fly   322 AGLPPSIAAAYFGGVPPQILPMPPATYAPTVAP------VSPVASQPVGSSTPTTSPRPSTSTKR 380
               ..|:|..|     .::......|:||...|      .|...:..:|.:...|...|.||...
Human   431 ---STSLAETY-----NRLTNQAGETFAPPRTPSYVGVSSSTSVNMSMGGTDGDTFSCPQTSLSM 487

  Fly   381 NSFSISAILAY 391
            ....:|..|.|
Human   488 QISGMSPQLQY 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	104/195 (53%)
TBX18	NP_001073977.1	Engrailed homology 1 repressor. /evidence=ECO:0000305	18..28
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..141		6/13 (46%)
		Nuclear localization signal. /evidence=ECO:0000305	36..40
		TBOX	139..334	CDD:238106	105/196 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940