DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doc1 and TBX3

DIOPT Version :9

Sequence 1:	NP_648283.1	Gene:	Doc1 / 39039	FlyBaseID:	FBgn0028789	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_057653.3	Gene:	TBX3 / 6926	HGNCID:	11602	Length:	743	Species:	Homo sapiens

Alignment Length:	490	Identity:	157/490 - (32%)
Similarity:	219/490 - (44%)	Gaps:	149/490 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IMQRIPDPFPSMLPFNMPHQQPHM-----MLPSRPTLPGVEAKLENNDLWQQFHKIGTEMIITKS 84
            ||.::.....:.:||:....|.|:     |.|........:..||..:||.||||.||||:||||
Human    64 IMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKS 128

  Fly    85 GRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPDSPAT 149
            ||||||..:|..|||:::|.|.:|::::...||||||..|:|:.||.|:|:.|:|||:|||||||
Human   129 GRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 193

  Fly   150 GAHWQSQALLFNKVKLTNNTLDSSG--------------------HIVLASMHKYQPRLHIIRSS 194
            |..|.|:.:.|:|:|||||..|..|                    ..:|.||||||||.||:|::
Human   194 GEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRAN 258

  Fly   195 ELTQLPWAPQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRESGQSR------------- 246
            ::.:||::..:.::||||||:||||||||:||:|||||||||||||::|..|
Human   259 DILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMR 323

  Fly   247 ------------------------CKRKLNSSGNSTL-----------ESEDDGSSVS------- 269
                                    |..:.:|...||:           |.|.|..:.|
Human   324 VFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPE 388

  Fly   270 SCDSPQAKRQRQDFEQDSTGSVSPA----YYGATHP----VANPMSPYLRH-------------- 312
            :||:  ||......|:......|||    .:.|..|    ..:..||..||
Human   389 ACDA--AKISTTTSEEPCRDKGSPAVKAHLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGA 451

  Fly   313 ----------------------------------------HLSYGPSGAAGLPPSIAA-AYFGGV 336
                                                    ||:.||....|..|.:|. .:|.|.
Human   452 EERRSPVREGTAPAKVEEARALPGKEAFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGH 516

  Fly   337 P----PQILPMPPATYAPTVAPVSPVASQPVGSST 367
            |    |....|..|..:...|.:.|:.:...|:||
Human   517 PLFLHPSQFAMGGAFSSMAAAGMGPLLATVSGAST 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	108/206 (52%)
TBX3	NP_057653.3	TBOX	104..307	CDD:238106	107/202 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..342		6/40 (15%)
		TBX	323..411	CDD:204975	14/89 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..465		20/109 (18%)
		Transcription repression	544..695		3/8 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..707
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840