Protein Alignment Doc1 and TBX6

DIOPT Version :9

• Sequence 1: NP_648283.1
• Gene: Doc1 / 39039
• FlyBaseID: FBgn0028789
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_004599.2
• Gene: TBX6 / 6911
• HGNCID: 11605
• Length: 436
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 158/386 - (40%)
• Similarity: 220/386 - (56%)
• Gaps: 69/386 - (17%)

  Fly    32 PFPSMLPFNMPHQQPHMMLPSRP----TLPGVEAKLENNDLWQQFHKIGTEMIITKSGRRMFPSM 92
            |.| :||..|..:.    .||.|    :||||...|||.:||::|..:||||||||:||||||:.
Human    65 PLP-LLPPAMGTEP----APSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPAC 124

  Fly    93 RVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQSQA 157
            |||::||:.||.|..||:::|:...||::.|.:|.|:|.|||:.|.|:|:|||||||||||..|.
Human   125 RVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQP 189

  Fly   158 LLFNKVKLTNNTLDSSGHIVLASMHKYQPRLHIIRSSELTQLPWAPQQAFVFPETEFVAVTAYQN 222
            :.|::|||||:|||..||::|.||||||||:|::|:::|....|....:|.||||.|::||||||
Human   190 VSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPETTFISVTAYQN 254

  Fly   223 DRITKLKIDNNPFAKGFRESGQ-------SRCKRKLNSSGNSTLESEDDGSSVSS-CDSPQAKRQ 279
            .:||:|||..|||||||||:|:       :|.||||.....:..|:...|.:... |||......
Human   255 PQITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPAATEAYGSGDTPGGPCDSTLGGDI 319

  Fly   280 RQ-DFEQ-----DSTGSVSP---------------AYYGA-TH-PVANP----------MSPYLR 311
            |: |.||     ::|.:.:|               |::|| :| |..:|          .:||..
Human   320 RESDPEQAPAPGEATAAPAPLCGGPSAEAYLLHPAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSA 384

  Fly   312 HHLSY----GPSGAAGLPPSI--AAAYFGGVPPQILPMP---PATYAPTVAPVSPVASQPV 363
            ..|..    |.||....||::  |..:..|.|   .|:|   |..|.       .|.|:|:
Human   385 AFLELPHGSGGSGYPAAPPAVPFAPHFLQGGP---FPLPYTAPGGYL-------DVGSKPM 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	108/193 (56%)
TBX6	NP_004599.2	TBOX	90..277	CDD:238106	108/186 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..339		19/67 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..379		3/18 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3129
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003805
OrthoInspector	1	1.000	-	-		otm41676
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.850