Protein Alignment Doc1 and TBX6

DIOPT Version :10

• Sequence 1: NP_648283.1
• Gene: Doc1 / 39039
• FlyBaseID: FBgn0028789
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_004599.2
• Gene: TBX6 / 6911
• HGNCID: 11605
• Length: 436
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 158/386 - (40%)
• Similarity: 220/386 - (56%)
• Gaps: 69/386 - (17%)

  Fly    32 PFPSMLPFNMPHQQPHMMLPSRP----TLPGVEAKLENNDLWQQFHKIGTEMIITKSGRRMFPSM 92
            |.| :||..|..:.    .||.|    :||||...|||.:||::|..:||||||||:||||||:.
Human    65 PLP-LLPPAMGTEP----APSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPAC 124

  Fly    93 RVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQSQA 157
            |||::||:.||.|..||:::|:...||::.|.:|.|:|.|||:.|.|:|:|||||||||||..|.
Human   125 RVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQP 189

  Fly   158 LLFNKVKLTNNTLDSSGHIVLASMHKYQPRLHIIRSSELTQLPWAPQQAFVFPETEFVAVTAYQN 222
            :.|::|||||:|||..||::|.||||||||:|::|:::|....|....:|.||||.|::||||||
Human   190 VSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPETTFISVTAYQN 254

  Fly   223 DRITKLKIDNNPFAKGFRESGQ-------SRCKRKLNSSGNSTLESEDDGSSVSS-CDSPQAKRQ 279
            .:||:|||..|||||||||:|:       :|.||||.....:..|:...|.:... |||......
Human   255 PQITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPAATEAYGSGDTPGGPCDSTLGGDI 319

  Fly   280 RQ-DFEQ-----DSTGSVSP---------------AYYGA-TH-PVANP----------MSPYLR 311
            |: |.||     ::|.:.:|               |::|| :| |..:|          .:||..
Human   320 RESDPEQAPAPGEATAAPAPLCGGPSAEAYLLHPAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSA 384

  Fly   312 HHLSY----GPSGAAGLPPSI--AAAYFGGVPPQILPMP---PATYAPTVAPVSPVASQPV 363
            ..|..    |.||....||::  |..:..|.|   .|:|   |..|.       .|.|:|:
Human   385 AFLELPHGSGGSGYPAAPPAVPFAPHFLQGGP---FPLPYTAPGGYL-------DVGSKPM 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	T-box_Drosocross-like	59..241	CDD:410332	104/181 (57%)
TBX6	NP_004599.2	T-box_TBX6_VegT-like	91..273	CDD:410316	104/181 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..339		19/67 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..379		3/18 (17%)