DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Doc1 and TBX2

DIOPT Version :9

Sequence 1:NP_648283.1 Gene:Doc1 / 39039 FlyBaseID:FBgn0028789 Length:391 Species:Drosophila melanogaster
Sequence 2:NP_005985.3 Gene:TBX2 / 6909 HGNCID:11597 Length:712 Species:Homo sapiens


Alignment Length:336 Identity:150/336 - (44%)
Similarity:198/336 - (58%) Gaps:59/336 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 LENNDLWQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWV 127
            ||..:||.||||:||||:||||||||||..:|.:|||:::|.|.:|:::|...||||||..|:|:
Human   109 LEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWM 173

  Fly   128 PAGGAEPQSPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLDSSGHIVLASMHKYQPRLHIIR 192
            .||.|:|:.|:|||:||||||||..|.::.:.|:|:|||||..|..|..:|.||||||||.||:|
Human   174 VAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVR 238

  Fly   193 SSELTQLPWAPQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRESGQSRC-KRKLNSSGN 256
            ::::.:||::..:.:|||||:|:||||||||:||:|||||||||||||::|..|. |||     .
Human   239 ANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRK-----Q 298

  Fly   257 STLES----------EDDG--SSVSSCDSPQAKRQRQDFEQDSTGSVSPAYYGATHPVANPMSPY 309
            .||.|          |.||  |..||||.|                  ||....|.|.|.| || 
Human   299 LTLPSLRLYEEHCKPERDGAESDASSCDPP------------------PAREPPTSPGAAP-SP- 343

  Fly   310 LRHHLSYG--PSGAAGLPPSIAAAYFGGVPPQILPMPPATYAPTVAPVSPVASQPV-GSSTPTTS 371
            ||.|.:..  .|.||...|.          |:.|....|.        :|:...|. .|::||..
Human   344 LRLHRARAEEKSCAADSDPE----------PERLSEERAG--------APLGRSPAPDSASPTRL 390

  Fly   372 PRPSTSTKRNS 382
            ..|..:.:|.|
Human   391 TEPERARERRS 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Doc1NP_648283.1 TBOX 58..245 CDD:238106 108/181 (60%)
TBX2NP_005985.3 T-box_TBX2_3-like 103..287 CDD:410314 106/177 (60%)
PHA03307 300..>467 CDD:223039 38/140 (27%)
TBX 305..383 CDD:403708 29/115 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..450 35/127 (28%)
Repression domain 1 (RD1) 518..601
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..687
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3585
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2837
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

Return to query results.
Submit another query.