DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc1 and Tbx21

DIOPT Version :9

Sequence 1:	NP_648283.1	Gene:	Doc1 / 39039	FlyBaseID:	FBgn0028789	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_062380.2	Gene:	Tbx21 / 57765	MGIID:	1888984	Length:	530	Species:	Mus musculus

Alignment Length:	410	Identity:	144/410 - (35%)
Similarity:	192/410 - (46%)	Gaps:	76/410 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PDPFPSMLPFNMPHQQPHMMLPSRPTLPG-VEAKLENNDLWQQFHKIGTEMIITKSGRRMFPSMR 93
            |||...:.|  .|.:.  ..||:...:.| :...|.|:.||.:|::..|||||||.||||||.:.
Mouse   110 PDPRAGLYP--GPRED--YALPAGLEVSGKLRVALSNHLLWSKFNQHQTEMIITKQGRRMFPFLS 170

  Fly    94 VSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSP-QRMYLHPDSPATGAHWQSQA 157
            .:::|||..:.|.:.:::|.:....:::...:||..|.||...| .|:|:|||||.|||||..|.
Mouse   171 FTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQE 235

  Fly   158 LLFNKVKLTNNTLDSSG---HIVLASMHKYQPRLHIIRSSELTQLPWAPQQA--------FVFPE 211
            :.|.|:|||||...|:.   .|||.|:|||||||||:..::     ..|:.|        |.|.|
Mouse   236 VSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVND-----GEPEAACSASNTHVFTFQE 295

  Fly   212 TEFVAVTAYQNDRITKLKIDNNPFAKGFRESGQSRCKRKLNS-----SGNSTLESEDDGSSVSSC 271
            |:|:|||||||..||:||||||||||||||:.:|.......|     ..|..|...|..|.:.|.
Mouse   296 TQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYASVDTSVPSPPGPNCQLLGGDPFSPLLSN 360

  Fly   272 DSPQAKRQRQDFEQDSTGSVSPAYYGAT---H----------------PVA-NPMSPYLRHHLSY 316
            ..|...|...|........:|..|:..|   |                |.| .|..||.|.....
Mouse   361 QYPVPSRFYPDLPGQPKDMISQPYWLGTPREHSYEAEFRAVSMKPTLLPSAPGPTVPYYRGQDVL 425

  Fly   317 GPSG----AAGLPPSIA-AAYFGGVPPQILPMPPATYAPTVAPVSPVASQPVGSS------TPTT 370
            .|..    |...||.:: |.:|.  |.:.|||.|..          .:|:..|||      ..:.
Mouse   426 APGAGWPVAPQYPPKMSPAGWFR--PMRTLPMDPGL----------GSSEEQGSSPSLWPEVTSL 478

  Fly   371 SPRPSTS------TKRNSFS 384
            .|.||.|      |||...|
Mouse   479 QPEPSDSGLGEGDTKRRRIS 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	94/199 (47%)
Tbx21	NP_062380.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		T-box	138..325	CDD:279278	91/191 (48%)
		T-box_assoc	<393..520	CDD:292794	29/118 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..530		19/67 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840