DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc1 and TBX20

DIOPT Version :9

Sequence 1:	NP_648283.1	Gene:	Doc1 / 39039	FlyBaseID:	FBgn0028789	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_001071121.1	Gene:	TBX20 / 57057	HGNCID:	11598	Length:	447	Species:	Homo sapiens

Alignment Length:	350	Identity:	139/350 - (39%)
Similarity:	187/350 - (53%)	Gaps:	63/350 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MLPSRPTLPGVE-----AKLENNDLWQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVL 108
            ::|:.|.:|..|     ..||..:||.:||::|||||||||||||||::|||.||::.||.|.||
Human    85 LIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVL 149

  Fly   109 LEMVPIGDCRYKFS--GSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLD 171
            :::||:.:.||:::  .|.|:.||.|:|..|.|:|:|||||.||.....|.:.|.|||||||.||
Human   150 MDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELD 214

  Fly   172 SSGHIVLASMHKYQPRLHIIR----SSELTQLPWAPQQAFVFPETEFVAVTAYQNDRITKLKIDN 232
            ..|||:|.||||||||:|||:    ::.|..|.....:.|:||||.|.|||||||..|||||||:
Human   215 QHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDS 279

  Fly   233 NPFAKGFRESGQ----------------SRCKRKLNSSG----------------NSTLESEDD- 264
            ||||||||:|.:                |..:..:.:.|                .|...:.|:
Human   280 NPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGEEDVLGDESQTTPNRGSAFTTSDNL 344

  Fly   265 --GSSVSSCDSPQAKRQRQDFEQDSTGSVSPAYYGATHPVANPMSPYLRHHLSYGPSGAAGLP-- 325
              .|.|||..|....:..|......|.:.|.| ....||:...:.||.|          .|:|
Human   345 SLSSWVSSSSSFPGFQHPQSLTALGTSTASIA-TPIPHPIQGSLPPYSR----------LGMPLT 398

  Fly   326 PSIAAAYFGGVPPQILPMPPATYAP 350
            ||..|:...|..|..    |:.:.|
Human   399 PSAIASSMQGSGPTF----PSFHMP 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	109/213 (51%)
TBX20	NP_001071121.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..81
		T-box	102..288	CDD:307177	106/185 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..340		2/23 (9%)
		DUF853	<357..>409	CDD:331106	14/62 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810