DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc1 and TBX22

DIOPT Version :9

Sequence 1:	NP_648283.1	Gene:	Doc1 / 39039	FlyBaseID:	FBgn0028789	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_001103348.1	Gene:	TBX22 / 50945	HGNCID:	11600	Length:	520	Species:	Homo sapiens

Alignment Length:	365	Identity:	130/365 - (35%)
Similarity:	197/365 - (53%)	Gaps:	76/365 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 VEAKLENNDLWQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYK--F 121
            ::.:|:.::||::||.|||||||||:|||||||:||.:.||:....|.|.:::||:...||:  :
Human    92 IQMELQGSELWKRFHDIGTEMIITKAGRRMFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVY 156

  Fly   122 SGSQWVPAGGAE-----PQSPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLDSSGHIVLASM 181
            ..|||:.||..:     |    |.|:|||||.:|..|..|.:.|:::|||||.:|..|||:|.||
Human   157 HSSQWMVAGNTDHLCIIP----RFYVHPDSPCSGETWMRQIISFDRMKLTNNEMDDKGHIILQSM 217

  Fly   182 HKYQPRLHIIRS------SELTQLPWAPQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFR 240
            |||:||:|:|..      |::..||....:.|.|.||||..||||||.:||||||:.||||||||
Human   218 HKYKPRVHVIEQGSSVDLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKGFR 282

  Fly   241 ESGQSRCKRKLNSSG-------------NSTLESEDDGSSVSSCDSPQAKRQRQDFEQDSTGSVS 292
            ::|::|        |             :.||:.:..|:               |.:..|:|| |
Human   283 DTGRNR--------GVLDGLLETYPWRPSFTLDFKTFGA---------------DTQSGSSGS-S 323

  Fly   293 P--AYYGATHPVANPMSPYLRHHLSYGPSGAAGLP------PS--------IAAAYFGGVPPQIL 341
            |  :..||..|:.:.:||.....:.:.|:.:.|:|      |:        |....|....|.:|
Human   324 PVTSSGGAPSPLNSLLSPLCFSPMFHLPTSSLGMPCPEAYLPNVNLPLCYKICPTNFWQQQPLVL 388

  Fly   342 PMP----PATYAPTVAPVSPVASQPVGSSTPTTSPRPSTS 377
            |.|    .:..:.::||:  :...|:.||...|:.:..:|
Human   389 PAPERLASSNSSQSLAPL--MMEVPMLSSLGVTNSKSGSS 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	97/198 (49%)
TBX22	NP_001103348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91
TBX22	NP_001103348.1	TBOX	91..287	CDD:238106	97/198 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910