DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc1 and tbx1

DIOPT Version :9

Sequence 1:	NP_648283.1	Gene:	Doc1 / 39039	FlyBaseID:	FBgn0028789	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	XP_005168668.1	Gene:	tbx1 / 368206	ZFINID:	ZDB-GENE-030805-5	Length:	519	Species:	Danio rerio

Alignment Length:	381	Identity:	136/381 - (35%)
Similarity:	194/381 - (50%)	Gaps:	96/381 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MLPSRPTLPGVEAKLENNDLWQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVLLEMVP 113
            ::...|.:..:..:||...||.:|:::|||||:||:||||||:.:|.:.|::..|.|.:|::.:|
Zfish   156 LVKKNPKVANINVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFLP 220

  Fly   114 IGDCRYK--FSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLDSSGHI 176
            :.|.||:  |..|.|:.||.|:|.:|.|::.||||||.||.|..|.:.|:|:|||||.||.:|||
Zfish   221 VDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHI 285

  Fly   177 VLASMHKYQPRLHII-----RSSELTQLPWAPQ--QAFVFPETEFVAVTAYQNDRITKLKIDNNP 234
            :|.|||:||||.|::     :.||    .:|.:  :.|||.||.|.|||||||.|||:|||.:||
Zfish   286 ILNSMHRYQPRFHVVYVDPRKDSE----KYAEENYKTFVFEETRFTAVTAYQNHRITQLKIASNP 346

  Fly   235 FAKGFRE------------------SGQSRCKRKLNS--SGNSTLESEDDGSSVSSCDSPQAKRQ 279
            ||||||:                  |..:|.:..::|  ..|.| |.||               .
Zfish   347 FAKGFRDCDPEDWPRNHRPGSLQIMSAFARTRNPMSSPPQQNGT-EKED---------------S 395

  Fly   280 RQDFEQDSTGS--------------VSPA--YYGATHPV---ANPMSP--------------YLR 311
            |:::::|.:|:              :|||  ..|..|.|   |.|.||              .|.
Zfish   396 RREYDRDPSGNPLHSDPTHQLMSRVLSPALPVLGGLHAVPLTAGPRSPPHELRLDGHPQPPDTLH 460

  Fly   312 HHLSYGPS------GAAGLP-----PSIAAAYFGGVPPQILPMPPATYAPTVAPVS 356
            ||....|:      ||...|     |||..   .|..|.:.|.....|:.|.||.:
Zfish   461 HHPYKYPATYEHYLGAKTRPSPYPSPSIRG---HGYHPHMNPTTANMYSATSAPTN 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	98/213 (46%)
tbx1	XP_005168668.1	TBOX	165..355	CDD:238106	97/193 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940