DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc1 and tbx4

DIOPT Version :9

Sequence 1:	NP_648283.1	Gene:	Doc1 / 39039	FlyBaseID:	FBgn0028789	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_570989.2	Gene:	tbx4 / 30070	ZFINID:	ZDB-GENE-991124-5	Length:	543	Species:	Danio rerio

Alignment Length:	468	Identity:	158/468 - (33%)
Similarity:	220/468 - (47%)	Gaps:	142/468 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 HMMLPSRPTLP----------GVEAKLENNDLWQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEE 101
            |:.||:.|:.|          .::..|.:.:||::||:.||||||||:|||||||.:|.::|:..
Zfish    31 HLGLPTTPSNPQNNEPDQSIENIKVVLHDRELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNP 95

  Fly   102 EASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQSQALLFNKVKLT 166
            :..|.:|.::||..|.||||..::|:.||.|||..|.|:|:|||||||||||..|.:.|.|:|||
Zfish    96 KTKYILLTDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLT 160

  Fly   167 NNTLDSSGHIVLASMHKYQPRLHIIRSSELTQLPWAPQQAF----------VFPETEFVAVTAYQ 221
            ||.||..|||:|.|||||||||||:::.|        ..||          ||.||.|::||:||
Zfish   161 NNHLDPFGHIILNSMHKYQPRLHIVKADE--------NNAFGSKNTAYCTHVFHETAFISVTSYQ 217

  Fly   222 NDRITKLKIDNNPFAKGFRESGQ-----SRC--------------KRKLNSSGN-------STLE 260
            |.:||:|||:|||||||||.|.:     ||.              :|.::|.|:       ..|.
Zfish   218 NHKITQLKIENNPFAKGFRGSDEGDLRVSRLQGKDYPVISKNMVRQRLISSHGHLSGKLSAGVLS 282

  Fly   261 SE---------DDGSSVSSCDSPQA-------KRQ---------------------RQDFEQDST 288
            |.         |.|..:.:.||.:|       .|:                     ::.:...::
Zfish   283 SHPQVLSHYQYDSGVPLPNSDSQEALSNSFTSSREPSLLYHCFKHRDNPRHLELGCKRPYLDTTS 347

  Fly   289 GSVSPAYYGATHPVANPMSPYLRH-----------HLSYG-----PSGAAG---LP-PSIAAAYF 333
            .:||..:|..:.|..:  ||.|.|           ...||     ..||.|   || ||:....:
Zfish   348 SAVSEEHYFRSPPSYD--SPLLSHPYCNEALGSREACMYGGLEGEGGGAVGTDDLPAPSLNCNMW 410

  Fly   334 GGVPP------------QILPM-----PPATYAPTVAPVSPVASQPVGSSTP------TTS---- 371
            ..|.|            |..|.     ..|:.|..|:..||...:|  ..||      ||.
Zfish   411 ASVQPYPRYGMQTVEAMQYQPFTAHFNSTASAASMVSHHSPSMQRP--HPTPPDLVTFTTQRVLP 473

  Fly   372 PRPSTSTKRNSFS 384
            |.||:::...|.|
Zfish   474 PTPSSASTSPSGS 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	104/201 (52%)
tbx4	NP_570989.2	TBOX	52..240	CDD:238106	104/195 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910