DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doc1 and TBX21

DIOPT Version :9

Sequence 1:	NP_648283.1	Gene:	Doc1 / 39039	FlyBaseID:	FBgn0028789	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_037483.1	Gene:	TBX21 / 30009	HGNCID:	11599	Length:	535	Species:	Homo sapiens

Alignment Length:	436	Identity:	142/436 - (32%)
Similarity:	201/436 - (46%)	Gaps:	99/436 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PDPFPSMLPFNMPHQQPHMMLPSRPTLPG-VEAKLENNDLWQQFHKIGTEMIITKSGRRMFPSMR 93
            |||...:.|  .|.:.  ..||:...:.| :...|.|:.||.:|::..|||||||.||||||.:.
Human   111 PDPRAGLYP--GPRED--YALPAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLS 171

  Fly    94 VSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSP-QRMYLHPDSPATGAHWQSQA 157
            .:::|||..:.|.:.:::|.:....:::...:||..|.||...| .|:|:|||||.|||||..|.
Human   172 FTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQE 236

  Fly   158 LLFNKVKLTNNTLDSSG---HIVLASMHKYQPRLHIIRSSELTQLPWAPQQA--------FVFPE 211
            :.|.|:|||||...|:.   .|||.|:|||||||||:..::     ..|:.|        |.|.|
Human   237 VSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVND-----GEPEAACNASNTHIFTFQE 296

  Fly   212 TEFVAVTAYQNDRITKLKIDNNPFAKGFRESGQSRCKRKLNSSGNSTLESE----------DDGS 266
            |:|:|||||||..||:||||||||||||||:.:|     :.:|.::::.|.          |..|
Human   297 TQFIAVTAYQNAEITQLKIDNNPFAKGFRENFES-----MYTSVDTSIPSPPGPNCQFLGGDHYS 356

  Fly   267 SVSSCDSPQAKRQRQDFEQDSTGSVSPAYY-GATH--------------PVANPMSP-----YLR 311
            .:.....|...|...|....:...|..||: ||..              |...|.:|     |.|
Human   357 PLLPNQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAEFRAVSMKPAFLPSAPGPTMSYYR 421

  Fly   312 HHLSYGPSG----AAGLPPSIA-AAYFGGVPPQILPM----------------PPATYAPTVAPV 355
            ......|..    |...||.:. |::|.  |.:.|||                ||..:. .:||:
Human   422 GQEVLAPGAGWPVAPQYPPKMGPASWFR--PMRTLPMEPGPGGSEGRGPEDQGPPLVWT-EIAPI 483

  Fly   356 SPVASQP-VG-----------------SSTPTTSPRPSTSTKRNSF 383
            .|.:|.. :|                 ||:|..:|.|........|
Human   484 RPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQF 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	94/199 (47%)
TBX21	NP_037483.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..109
		T-box_TBX21	136..326	CDD:410329	91/194 (47%)
		T-box_assoc	<394..525	CDD:406561	27/133 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..535		17/84 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840