Protein Alignment Doc1 and Tbx3

DIOPT Version :10

• Sequence 1: NP_648283.1
• Gene: Doc1 / 39039
• FlyBaseID: FBgn0028789
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_035665.2
• Gene: Tbx3 / 21386
• MGIID: 98495
• Length: 741
• Species: Mus musculus
• Alignment Length: 492
• Identity: 160/492 - (32%)
• Similarity: 221/492 - (44%)
• Gaps: 155/492 - (31%)

  Fly    25 IMQRIPDPFPSMLPFNMPHQQPHM-----MLPSRPTLPGVEAKLENNDLWQQFHKIGTEMIITKS 84
            ||.::.....:.:||:....|.|:     |.|........:..||..:||.||||.||||:||||
Mouse    64 IMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEDVEDDPKVHLEAKELWDQFHKRGTEMVITKS 128

  Fly    85 GRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPDSPAT 149
            ||||||..:|..|||:::|.|.:|::::...||||||..|:|:.||.|:|:.|:|||:|||||||
Mouse   129 GRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 193

  Fly   150 GAHWQSQALLFNKVKLTNNTLDSSG--------------------HIVLASMHKYQPRLHIIRSS 194
            |..|.|:.:.|:|:|||||..|..|                    ..:|.||||||||.||:|::
Mouse   194 GEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRAN 258

  Fly   195 ELTQLPWAPQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRESGQSRC-KRK-------- 250
            ::.:||::..:.::||||||:||||||||:||:|||||||||||||::|..|. |||
Mouse   259 DILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMR 323

  Fly   251 -------------------------------LNSSGNSTL------ESEDDGSSVS-------SC 271
                                           ::..|.|.|      |:|.|..:.|       :|
Mouse   324 VFEERHKKETSDESSSEQAAFNCFAQASSPAVSIVGTSNLKDLCPSEAESDAEAESKEEHGPEAC 388

  Fly   272 DSPQAKRQRQDFEQDSTGSVSPAYYGATHPVANP-----------MSPYLRH------------- 312
            |:  ||......|:......|||......| |.|           .||..||
Mouse   389 DA--AKISTTTAEEPGRDKGSPATRAQLFP-AEPSRARDTARLDKASPDSRHSPATISSSTRVPG 450

  Fly   313 ----------------------------------------HLSYGPSGAAGLPPSIAA-AYFGGV 336
                                                    ||:.||....|..|.:|. .:|.|.
Mouse   451 ADERRSPGREGPVATKVDEARAIPAKDAFAPLSVQTDATAHLAQGPLPGLGFAPGLAGQQFFNGH 515

  Fly   337 PPQILPMPPATYA------PTVAPVSPVASQPVGSST 367
            |   |.:.|..:|      ...|.:.|:.:...|:||
Mouse   516 P---LFLHPGQFAMGGAFSSMAAGMGPLLATVSGAST 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	T-box_Drosocross-like	59..241	CDD:410332	106/201 (53%)
Tbx3	NP_035665.2	T-box_TBX2_3-like	101..305	CDD:410314	106/203 (52%)
		TBX	323..402	CDD:432659	12/80 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	369..469		19/102 (19%)