DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc1 and tbx6

DIOPT Version :9

Sequence 1:	NP_648283.1	Gene:	Doc1 / 39039	FlyBaseID:	FBgn0028789	Length:	391	Species:	Drosophila melanogaster
Sequence 2:	NP_705952.2	Gene:	tbx6 / 192294	ZFINID:	ZDB-GENE-020416-5	Length:	874	Species:	Danio rerio

Alignment Length:	453	Identity:	156/453 - (34%)
Similarity:	225/453 - (49%)	Gaps:	97/453 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QQLAHEIYRQQIMQRIPDPF--------PSMLPFNMPHQQPHMMLPSRPTLP--GVEAKLENNDL 68
            |:|:...||.:.:...|...        |::|       :||....| |..|  .|..:|||..|
Zfish    15 QRLSDCYYRDRDVPLYPSTCEMAARALPPALL-------KPHANTDS-PATPQDSVRMELENAGL 71

  Fly    69 WQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAE 133
            |:||..:|||||:||.||||||.:||.||||.....|.:||::||:...||:|..:.|...||||
Zfish    72 WKQFSTVGTEMIVTKKGRRMFPQLRVKLSGLNPSLRYILLLDIVPVDSSRYRFQDNSWQVVGGAE 136

  Fly   134 PQSPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLDSSGHIVLASMHKYQPRLHIIRSSELTQ 198
            .:.|.|:::||||||||.|||::.:.|::.||||||||:.|:|:|.|:|:||||:|:|.:.::
Zfish   137 ARLPDRVFIHPDSPATGEHWQNRTISFHRAKLTNNTLDAQGYIILHSLHRYQPRVHVIEARDV-- 199

  Fly   199 LPWA-PQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRESG-------QSRCKRKLNSSG 255
            |.|. .|.:|.||||:|:.||||||::||:|||::|||||||||:|       ::|.|||:.||.
Zfish   200 LMWGRTQHSFTFPETQFITVTAYQNNKITELKINSNPFAKGFRENGMNCKKQREARLKRKITSSQ 264

  Fly   256 NSTLESEDDGSSVSSCDSPQAKRQRQDFEQDSTGSVSPAY---------YGATHPVANPMSPYLR 311
            ...|:.|    |...|||.:...|..|....:...::.|.         ..::||........|.
Zfish   265 EECLDIE----SCDPCDSTELLPQSVDLPSSALTIMNTALPITDSGFHTEVSSHPDQTDSDQTLV 325

  Fly   312 HHLSYGPSGAAGLPPSI-------------------------AAAYFGGVP-PQI-----LPMPP 345
            ...::..|   .:|.|:                         .:.|....| ||:     :|...
Zfish   326 LEQAFLTS---EMPSSMESQQQTTSETNVNNALMDETGQMMDLSGYTSSFPTPQLSSHTSVPQSS 387

  Fly   346 ATYA------------PTVAPVSPVASQPVGSSTP----------TTSPRPSTSTKRNSFSIS 386
            :.|:            |..:.:|...|.|..||.|          |..|..:||...:..|||
Zfish   388 SMYSVVSSTQSSDLELPQASSISSPHSMPAYSSIPSAEYPGVNSSTAMPASTTSLSDSYPSIS 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	103/194 (53%)
tbx6	NP_705952.2	TBOX	62..247	CDD:238106	103/186 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..453		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..551
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..695
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800