Protein Alignment Doc1 and tbx6

DIOPT Version :10

• Sequence 1: NP_648283.1
• Gene: Doc1 / 39039
• FlyBaseID: FBgn0028789
• Length: 391
• Species: Drosophila melanogaster
• Sequence 2: NP_705952.2
• Gene: tbx6 / 192294
• ZFINID: ZDB-GENE-020416-5
• Length: 874
• Species: Danio rerio
• Alignment Length: 453
• Identity: 156/453 - (34%)
• Similarity: 225/453 - (49%)
• Gaps: 97/453 - (21%)

  Fly    14 QQLAHEIYRQQIMQRIPDPF--------PSMLPFNMPHQQPHMMLPSRPTLP--GVEAKLENNDL 68
            |:|:...||.:.:...|...        |::|       :||....| |..|  .|..:|||..|
Zfish    15 QRLSDCYYRDRDVPLYPSTCEMAARALPPALL-------KPHANTDS-PATPQDSVRMELENAGL 71

  Fly    69 WQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAE 133
            |:||..:|||||:||.||||||.:||.||||.....|.:||::||:...||:|..:.|...||||
Zfish    72 WKQFSTVGTEMIVTKKGRRMFPQLRVKLSGLNPSLRYILLLDIVPVDSSRYRFQDNSWQVVGGAE 136

  Fly   134 PQSPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLDSSGHIVLASMHKYQPRLHIIRSSELTQ 198
            .:.|.|:::||||||||.|||::.:.|::.||||||||:.|:|:|.|:|:||||:|:|.:.::
Zfish   137 ARLPDRVFIHPDSPATGEHWQNRTISFHRAKLTNNTLDAQGYIILHSLHRYQPRVHVIEARDV-- 199

  Fly   199 LPWA-PQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRESG-------QSRCKRKLNSSG 255
            |.|. .|.:|.||||:|:.||||||::||:|||::|||||||||:|       ::|.|||:.||.
Zfish   200 LMWGRTQHSFTFPETQFITVTAYQNNKITELKINSNPFAKGFRENGMNCKKQREARLKRKITSSQ 264

  Fly   256 NSTLESEDDGSSVSSCDSPQAKRQRQDFEQDSTGSVSPAY---------YGATHPVANPMSPYLR 311
            ...|:.|    |...|||.:...|..|....:...::.|.         ..::||........|.
Zfish   265 EECLDIE----SCDPCDSTELLPQSVDLPSSALTIMNTALPITDSGFHTEVSSHPDQTDSDQTLV 325

  Fly   312 HHLSYGPSGAAGLPPSI-------------------------AAAYFGGVP-PQI-----LPMPP 345
            ...::..|   .:|.|:                         .:.|....| ||:     :|...
Zfish   326 LEQAFLTS---EMPSSMESQQQTTSETNVNNALMDETGQMMDLSGYTSSFPTPQLSSHTSVPQSS 387

  Fly   346 ATYA------------PTVAPVSPVASQPVGSSTP----------TTSPRPSTSTKRNSFSIS 386
            :.|:            |..:.:|...|.|..||.|          |..|..:||...:..|||
Zfish   388 SMYSVVSSTQSSDLELPQASSISSPHSMPAYSSIPSAEYPGVNSSTAMPASTTSLSDSYPSIS 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc1	NP_648283.1	T-box_Drosocross-like	59..241	CDD:410332	100/182 (55%)
tbx6	NP_705952.2	T-box_TBX6	62..243	CDD:410322	100/182 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..396		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..453		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..551
		PHA03247	<481..799	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	563..626
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	664..695
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	720..776