Protein Alignment Doc2 and TBX18

DIOPT Version :9

• Sequence 1: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001073977.1
• Gene: TBX18 / 9096
• HGNCID: 11595
• Length: 607
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 169/503 - (33%)
• Similarity: 231/503 - (45%)
• Gaps: 125/503 - (24%)

  Fly    35 PMLPIPMPRHVIMPPRVTLPGVEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDE 99
            |..|:|.|:    .|||.|.|.|       |||:||:|||||||||:||||||:||:.:|||:..
Human   129 PGTPLPSPQ----APRVDLQGAE-------LWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPH 182

  Fly   100 SNYCVLLEMVPIGDCRYK--FSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKL 162
            ..|.:.:::||:.:.||:  :..|:|:.||.|:...|.|:|:||||||:|..|..|.|.|:|:||
Human   183 QQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKL 247

  Fly   163 TNNTLDNSGHIVLASMHKYQPRLHVIRT---ADLAQIPWAPQ----QAFVFAETEFVAVTAYQND 220
            |||.||:.|||:|.||||||||:||||.   .||:.|...|.    :||.|.||.|..||||||.
Human   248 TNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQ 312

  Fly   221 RITKLKIDNNPFAKGFRETGQSRCK-----------RKMSSSPTGEDQDQSPSLSHSQSQSESDM 274
            :||:||||.||||||||::|::|..           |....:.|.||   .|.:....:.|.|.:
Human   313 QITRLKIDRNPFAKGFRDSGRNRMGLEALVESYAFWRPSLRTLTFED---IPGIPKQGNASSSTL 374

  Fly   275 SPTKGGGETAGGTSSIGDSD--------GPQIKRLRSNGSACSLSSSLDDQSVPGASSLALGS-- 329
            ....|.|..|.....:..|.        ||...:|      |||:.:  |.|....|.|.|..
Human   375 LQGTGNGVPATHPHLLSGSSCSSPAFHLGPNTSQL------CSLAPA--DYSACARSGLTLNRYS 431

  Fly   330 ------------------PPPHLHSHSHPHPLQARSASSVFMQ------------HFQQNMQ-SL 363
                              .||...|:     :...|::||.|.            ....:|| |.
Human   432 TSLAETYNRLTNQAGETFAPPRTPSY-----VGVSSSTSVNMSMGGTDGDTFSCPQTSLSMQISG 491

  Fly   364 LRPSLVDL----ACTYFGRPHEYGGAIQASPMYPPAAMLQAGLGPHPGL---------------- 408
            :.|.|..:    :...|.....:.|:.....::.|.|:........|.|
Human   492 MSPQLQYIMPSPSSNAFATNQTHQGSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLG 556

  Fly   409 -----------NLPPGVSGADLISDESGAEELELD---VGSETSTLEQ 442
                       .||| |.|..|:|  ||.::...|   :||.|.:..|
Human   557 SSPSGTMTDRQMLPP-VEGVHLLS--SGGQQSFFDSRTLGSLTLSSSQ 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	106/195 (54%)
TBX18	NP_001073977.1	Engrailed homology 1 repressor. /evidence=ECO:0000305	18..28
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..141		5/15 (33%)
		Nuclear localization signal. /evidence=ECO:0000305	36..40
		TBOX	139..334	CDD:238106	110/201 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910