Protein Alignment Doc2 and EOMES

DIOPT Version :9

• Sequence 1: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001265111.1
• Gene: EOMES / 8320
• HGNCID: 3372
• Length: 705
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 147/448 - (32%)
• Similarity: 205/448 - (45%)
• Gaps: 105/448 - (23%)

  Fly    53 LPG----VEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGD 113
            :||    ..:.|.|..||.:||:..|||||||.||||||.:..:::||...::|.|.:|:|....
Human   260 VPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADP 324

  Fly   114 CRYKFSGSQWVPAGGAE-PQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNN---TLDNSGHIV 174
            ..::|.|.:||..|.|: .....:||:||:||.||:||..|.|.|.|:|||||   ..:|:..||
Human   325 NHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIV 389

  Fly   175 LASMHKYQPRLHVIRTA-----DLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKIDNNPFAK 234
            |.|:||||||||::...     ||.: | :..|.|.|:||:|:|||||||..||:||||:|||||
Human   390 LQSLHKYQPRLHIVEVTEDGVEDLNE-P-SKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAK 452

  Fly   235 GFRETGQSRCKRKMSSSPTGEDQDQSPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQIK 299
            |||:        ...|..|..:.|:   |:.|.:.|........||   ..|..|....  |.:.
Human   453 GFRD--------NYDSMYTASENDR---LTPSPTDSPRSHQIVPGG---RYGVQSFFPE--PFVN 501

  Fly   300 RLRS----NGSACSLSSSLDDQSVPGASSLALGSPPPHLHSHSHPH-----PLQARSASSVFMQH 355
            .|..    ||          :::||..:.|.  ||.......:.|.     |:|....:.:.:..
Human   502 TLPQARYYNG----------ERTVPQTNGLL--SPQQSEEVANPPQRWLVTPVQQPGTNKLDISS 554

  Fly   356 FQ-QNMQSLLRPSLVDLACTYFGRPHEYGGAIQASPM--------YP----PAAMLQAGLGPHP- 406
            :: :...|.|.|               ||  |::.|:        ||    ||.....|.|.:.
Human   555 YESEYTSSTLLP---------------YG--IKSLPLQTSHALGYYPDPTFPAMAGWGGRGSYQR 602

  Fly   407 --GLNLP------PGVSGADLISDESGAEELELDVGSETSTLEQSTQEQPLEQPSTRS 456
              ...||      |.|...|.:|.|...||    :||       |..|.|   ||.:|
Human   603 KMAAGLPWTSRTSPTVFSEDQLSKEKVKEE----IGS-------SWIETP---PSIKS 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	94/199 (47%)
EOMES	NP_001265111.1	TBOX	267..460	CDD:238106	93/202 (46%)
		T-box_assoc	482..703	CDD:292794	46/213 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910