Protein Alignment Doc2 and TBX6

DIOPT Version :9

• Sequence 1: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_004599.2
• Gene: TBX6 / 6911
• HGNCID: 11605
• Length: 436
• Species: Homo sapiens
• Alignment Length: 445
• Identity: 168/445 - (37%)
• Similarity: 233/445 - (52%)
• Gaps: 98/445 - (22%)

  Fly    26 MQRIPDPFPPMLPIPMPRHVIMPPRV-------------TLPGVEMTLQNDDLWKQFHQIGTEMI 77
            |:..|.......|:|     ::||.:             :||||.::|:|.:|||:|..:|||||
Human    53 MEAAPRTLAAHPPLP-----LLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMI 112

  Fly    78 ITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPD 142
            |||:||||||:.|:||:||:.|:.|..||:::|:...||::.|.:|.|:|.|||:.|.|:|:|||
Human   113 ITKAGRRMFPACRVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPD 177

  Fly   143 SPATGAHWQAQPILFNKVKLTNNTLDNSGHIVLASMHKYQPRLHVIRTADLAQIPWAPQQAFVFA 207
            ||||||||..||:.|::|||||:|||..||::|.||||||||:|::|.|.|....|....:|.|.
Human   178 SPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFP 242

  Fly   208 ETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRCKRKMSSSPTGEDQDQSPSLSHSQSQSES 272
            ||.|::||||||.:||:|||..|||||||||.|:: |||:..:....:.:...|:.:.:.
Human   243 ETTFISVTAYQNPQITQLKIAANPFAKGFRENGRN-CKRERDARVKRKLRGPEPAATEAY----- 301

  Fly   273 DMSPTKGGGETAGG--TSSIG----DSDGPQIKRLRSNGSACSLSSSLDDQSVPGASS-----LA 326
                  |.|:|.||  .|::|    :||..|..   :.|.|.:..:.|  ...|.|.:     .|
Human   302 ------GSGDTPGGPCDSTLGGDIRESDPEQAP---APGEATAAPAPL--CGGPSAEAYLLHPAA 355

  Fly   327 LGSPPPHL--HSHSHPH-PLQARSA--SSVFMQHFQQNMQSLLRPSLVDLACTYFGRPHEYGGAI 386
            ....|.||  .|.|.|. |...|||  |:.|::                       .||..||:
Human   356 FHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLE-----------------------LPHGSGGS- 396

  Fly   387 QASPMYPPAA-----MLQAGLGPHPGLNLPPGVSGADLISDESGAEELELDVGSE 436
             ..|..|||.     .||.|..|.| ...|.|.                |||||:
Human   397 -GYPAAPPAVPFAPHFLQGGPFPLP-YTAPGGY----------------LDVGSK 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	108/186 (58%)
TBX6	NP_004599.2	TBOX	90..277	CDD:238106	108/186 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..339		20/82 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..379		7/18 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3129
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003805
OrthoInspector	1	1.000	-	-		otm41676
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6331
SonicParanoid	1	1.000	-	-		X4271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.880