Protein Alignment Doc2 and TBX2

DIOPT Version :10

• Sequence 1: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_005985.3
• Gene: TBX2 / 6909
• HGNCID: 11597
• Length: 712
• Species: Homo sapiens
• Alignment Length: 449
• Identity: 157/449 - (34%)
• Similarity: 224/449 - (49%)
• Gaps: 70/449 - (15%)

  Fly    57 EMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGDCRYKFSGS 121
            ::||:..:||.|||::||||:||||||||||..::.||||:.::.|.:|:::|...||||||..|
Human   106 KVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNS 170

  Fly   122 QWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGHIVLASMHKYQPRLH 186
            :|:.||.|:|:.|:|||:||||||||..|.|:|:.|:|:|||||..|..|..:|.||||||||.|
Human   171 RWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFH 235

  Fly   187 VIRTADLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRC-KRKMSS 250
            ::|..|:.::|::..:.:||.||:|:||||||||:||:|||||||||||||:||..|. |||..:
Human   236 IVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLT 300

  Fly   251 SPT-------------GEDQDQS----PSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQI 298
            .|:             |.:.|.|    |......:...:..||.:.....|...|...||| |:.
Human   301 LPSLRLYEEHCKPERDGAESDASSCDPPPAREPPTSPGAAPSPLRLHRARAEEKSCAADSD-PEP 364

  Fly   299 KRLRSNGSACSLSSSLDDQSVPGASSLALGSPPPHLHSHSHP----HPLQARSASSVFMQHFQQN 359
            :||....:...|..|    ..|.::|....:.|........|    .|.::.......::..::.
Human   365 ERLSEERAGAPLGRS----PAPDSASPTRLTEPERARERRSPERGKEPAESGGDGPFGLRSLEKE 425

  Fly   360 MQSLLRPSLVDLACTYFGRPHEYGGAIQ-----------ASPMYPPAAMLQAGLGPHPGLNLPPG 413
            .....|..        .||.....|..|           |||:         |.|..|||.....
Human   426 RAEARRKD--------EGRKEAAEGKEQGLAPLVVQTDSASPL---------GAGHLPGLAFSSH 473

  Fly   414 VSGADLISDESGAEELELDVGSETSTLEQSTQEQPLEQP---STRSKGFSISAILGGGS 469
            :.|..........:.|.|..|..|.            .|   |....|..::::.|||:
Human   474 LHGQQFFGPLGAGQPLFLHPGQFTM------------GPGAFSAMGMGHLLASVAGGGN 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	T-box_Drosocross-like	56..238	CDD:410332	104/180 (58%)
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	104/180 (58%)
		PHA03307	300..>467	CDD:223039	32/188 (17%)
		TBX	305..383	CDD:432659	16/82 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..450		26/149 (17%)
		Repression domain 1 (RD1). /evidence=ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:30599067	518..601		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..687