Protein Alignment Doc2 and TBX1

DIOPT Version :10

• Sequence 1: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: XP_016884416.2
• Gene: TBX1 / 6899
• HGNCID: 11592
• Length: 522
• Species: Homo sapiens
• Alignment Length: 379
• Identity: 129/379 - (34%)
• Similarity: 195/379 - (51%)
• Gaps: 86/379 - (22%)

  Fly    55 GVEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGDCRYK-- 117
            ||.:.|:...||.:|:|:|||||:||:||||||:.::.:.|::..::|.:|::.||:.|.||:
Human   118 GVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYA 182

  Fly   118 FSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGHIVLASMHKYQ 182
            |..|.|:.||.|:|.:|.|::.||||||.||.|..|.:.|:|:|||||.||::|||:|.|||:||
Human   183 FHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQ 247

  Fly   183 PRLHVIRT---ADLAQIPWAPQQAFVFAETEFVAVTAYQNDR------------------ITKLK 226
            ||.||:..   .|..:......:.|||.||.|.|||||||.|                  ||:||
Human   248 PRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRVRACGEDLSGFNASGKAGITQLK 312

  Fly   227 IDNNPFAKGFRE------------------TGQSRCKRKMSS--SPTGEDQDQS----------- 260
            |.:||||||||:                  :..:|.:..::|  .|:|.::|.:
Human   313 IASNPFAKGFRDCDPEDWPRNHRPGALPLMSAFARSRNPVASPTQPSGTEKDAAEARREFQRDAG 377

  Fly   261 -PSL----SHSQSQSESDMSPTKGGGETAGGTSSIGDSDG-------PQIKRLRSNGSACSL--- 310
             |::    :|........:||:..|...|||...:..:.|       |:: ||.:.|::..|
Human   378 GPAVLGDPAHPPQLLARVLSPSLPGAGGAGGLVPLPGAPGGRPSPPNPEL-RLEAPGASEPLHHH 441

  Fly   311 -----SSSLDDQSVPGASSLALGSP---------PPHLHSHSHPHPLQARSASS 350
                 :::.|...  ||.|.....|         .||.|.|.|.||:...:|::
Human   442 PYKYPAAAYDHYL--GAKSRPAPYPLPGLRGHGYHPHAHPHHHHHPVSPAAAAA 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	T-box_Drosocross-like	56..238	CDD:410332	95/204 (47%)
TBX1	XP_016884416.2	T-box_TBX1_10-like	118..324	CDD:410313	96/205 (47%)