Protein Alignment Doc2 and TBXT

DIOPT Version :10

• Sequence 1: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001353214.1
• Gene: TBXT / 6862
• HGNCID: 11515
• Length: 436
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 141/435 - (32%)
• Similarity: 203/435 - (46%)
• Gaps: 86/435 - (19%)

  Fly    60 LQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGDCRYKFSGSQWV 124
            |:..:||.:|.::..|||:||:||||||.::::||||:..:.|..||:.|...:.|:|:...:||
Human    46 LEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWV 110

  Fly   125 PAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGHIVLASMHKYQPRLHVIR 189
            |.|..|||:|..:|:|||||..||||...|:.|:||||||. |:..|.|:|.|:|||:||:|::|
Human   111 PGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNK-LNGGGQIMLNSLHKYEPRIHIVR 174

  Fly   190 TADLAQIPWAPQQ---AFVFAETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRCKRKMSSS 251
            ..       .||:   :..|.||:|:|||||||:.||.|||..|||||.|.:..:....::|...
Human   175 VG-------GPQRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEE 232

  Fly   252 PTGEDQDQSPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQIKRLRSNGSACSLSSSLDD 316
            |   ...|.|..|.|             ||....|||::.....|.    ...|.|.||.|:...
Human   233 P---GDSQQPGYSQS-------------GGWLLPGTSTLCPPANPH----PQFGGALSLPSTHSC 277

  Fly   317 QSVPGASSLALGSPPPHLHSHSHPHPLQA-RSASSVFMQHFQQNMQSL---LRPSLVDLACTYFG 377
            ...|...| ...||.|..::|.:..|..: .|.:.:.|.....|..||   ..||::.::
Human   278 DRYPTLRS-HRSSPYPSPYAHRNNSPTYSDNSPACLSMLQSHDNWSSLGMPAHPSMLPVS----- 336

  Fly   378 RPHEYGGAIQASP-----MYP--------------PAAMLQAGLGPH-----PGLNLP------- 411
              |      .|||     .||              .||.:..|||..     |....|
Human   337 --H------NASPPTSSSQYPSLWSVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLTHPVSA 393

  Fly   412 PGVSGADLISDESGAEEL---ELDVGSETSTLEQSTQEQPLEQPS 453
            |..||:.|....:.|.::   :.|..::...:...|   |:..||
Human   394 PSSSGSPLYEGAAAATDIVDSQYDAAAQGRLIASWT---PVSPPS 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	T-box_Drosocross-like	56..238	CDD:410332	87/180 (48%)
TBXT	NP_001353214.1	T-box_TBXT	41..219	CDD:410328	87/180 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..309		7/29 (24%)