DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc2 and tbx1

DIOPT Version :9

Sequence 1:	NP_648282.1	Gene:	Doc2 / 39038	FlyBaseID:	FBgn0035956	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001030290.1	Gene:	tbx1 / 619587	XenbaseID:	XB-GENE-478084	Length:	463	Species:	Xenopus tropicalis

Alignment Length:	395	Identity:	146/395 - (36%)
Similarity:	204/395 - (51%)	Gaps:	79/395 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PRVTLPGVEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGD 113
            |:|.  .:.:.|:...||.:|:|:|||||:||:||||||:.::.:.|::..::|.:|::.||:.|
Frog   105 PKVA--NITVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFVPVDD 167

  Fly   114 CRYK--FSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGHIVLA 176
            .||:  |..|.|:.||.|:|.:|.|::.||||||.||.|..|.:.|:|:|||||.||::|||:|.
Frog   168 KRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILN 232

  Fly   177 SMHKYQPRLHVIRT---ADLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKIDNNPFAKGFRE 238
            |||:||||.||:..   .|..:......:.|||.||.|.|||||||.|||:|||.:||||||||:
Frog   233 SMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRD 297

  Fly   239 ------------------TGQSRCKRKMSSSP-TGEDQDQSPSLSHSQSQSESDMSPTKGGGETA 284
                              ...:|.:..:||.| .|.|:|     ...:.:.|.|.|
Frog   298 CDPEDWPRNHRPGSLPLMNAFARSRNPVSSPPQNGSDKD-----GDGRREYERDTS--------- 348

  Fly   285 GGTSSIGDSDGPQI-KRLRSNGSACSLSSSLDDQSVPGA-SSLALGSP-PPH---LHSHS----- 338
             ||...||:...|: .|:        ||.||   .|||. ..|:.|.| |||   |..||
Frog   349 -GTPLHGDAAHQQLMSRV--------LSPSL---PVPGGLVPLSTGRPSPPHELRLDPHSQGSEP 401

  Fly   339 -HPHPLQARSASSVFMQHFQQNMQSLLRPSLVDLACTYFGRPHEYGGAIQASPMYPPAAMLQAGL 402
             |.||.:       :...:...:.:..||:...|       |...|......||.|.||.:.:|.
Frog   402 LHHHPYK-------YPTSYDHYLGAKTRPAPYPL-------PSIRGHGYHHHPMNPAAANMYSGA 452

  Fly   403 GPHPG 407
            |. ||
Frog   453 GA-PG 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	95/209 (45%)
tbx1	NP_001030290.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..103
		T-box	112..297	CDD:366363	94/184 (51%)
		T-box	114..297		94/182 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..354		12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..405		16/40 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100