DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc2 and tbx18

DIOPT Version :9

Sequence 1:	NP_648282.1	Gene:	Doc2 / 39038	FlyBaseID:	FBgn0035956	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_705951.1	Gene:	tbx18 / 572713	ZFINID:	ZDB-GENE-020529-2	Length:	554	Species:	Danio rerio

Alignment Length:	479	Identity:	167/479 - (34%)
Similarity:	224/479 - (46%)	Gaps:	114/479 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PDPFPPMLPIPMPRH---VIMPPRVTLPGVEM--TLQNDDLWKQFHQIGTEMIITKSGRRMFPSM 89
            |:|...:|..|.|..   .::....|..|.||  .||..||||:||:|||||||||:||||||:|
Zfish    78 PEPEDVLLDSPQPASQGAQVLVQSATSSGEEMRVDLQGSDLWKRFHEIGTEMIITKAGRRMFPAM 142

  Fly    90 RLSVSGLEDESNYCVLLEMVPIGDCRYK--FSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQA 152
            |:.::||:....|.:.:::||:.:.||:  :..|:|:.||.|:...|.|:|:||||||:|..|..
Zfish   143 RVKIAGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMR 207

  Fly   153 QPILFNKVKLTNNTLDNSGHIVLASMHKYQPRLHVIRT---ADLAQIPWAPQ----QAFVFAETE 210
            |.|.|:|:|||||.||:.|||:|.||||||||:||||.   .:|:.:...|.    :||.|.||.
Zfish   208 QVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKECGEELSPVKAVPTGDGVKAFSFTETV 272

  Fly   211 FVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRCKRKMSSSPTGEDQD-QSPSLSHSQSQSESDM 274
            |..||||||.:||:||||.||||||||::|::|    |......|... ..|||  .....|..:
Zfish   273 FTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNR----MGLEALVESYAFWRPSL--RTLTFEDIL 331

  Fly   275 SPTKGGGETAGGTSSIGDSDGPQIKRLRSNGSACSLSSSLDDQSVPGASSLALGSPPPHLHSHSH 339
            ..||.|  .||....:|             .||..||||    |.|        ||..||.|.:.
Zfish   332 GITKQG--AAGSHGVVG-------------SSAHLLSSS----SCP--------SPTFHLGSGAG 369

  Fly   340 P-----------HPLQ----------------------ARSASSVFMQHFQQNMQSLLRPSLVDL 371
            |           |||.                      :.|.||.::...:...          .
Zfish   370 PVCDYSTCSRTSHPLHRYGPSLSADSYSRLTSPTADAFSTSRSSTYVSGTESEA----------F 424

  Fly   372 ACTYFGRPHEYGGAIQASPMYPPAAML---------------QAGLGPHPGLNL--PPGVSGADL 419
            :||..|.|      ||...|....:.|               |:..|.:.|..|  |.|:.|.:.
Zfish   425 SCTQTGLP------IQIHSMPSTTSQLQYLMPGHAHNAFSTNQSTQGSYNGFRLHNPYGLYGYNF 483

  Fly   420 ISDESGAEELELDVGSETSTLEQS 443
            .:....|...|....::||.|..|
Zfish   484 STSPRLATSPEKAAATQTSFLGSS 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	107/197 (54%)
tbx18	NP_705951.1	TBOX	109..304	CDD:238106	105/194 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010