DRSC/TRiP Functional Genomics Resources

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Protein Alignment Doc2 and TBX20

DIOPT Version :10

Sequence 1:NP_648282.1 Gene:Doc2 / 39038 FlyBaseID:FBgn0035956 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_001071121.1 Gene:TBX20 / 57057 HGNCID:11598 Length:447 Species:Homo sapiens


Alignment Length:399 Identity:151/399 - (37%)
Similarity:205/399 - (51%) Gaps:80/399 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 DPFPPMLPIPMPRHVIMPPRVTLPGVEM-----TLQNDDLWKQFHQIGTEMIITKSGRRMFPSMR 90
            :|..|..||             :|..||     :|:..:||.:||::|||||||||||||||::|
Human    83 EPLIPTTPI-------------IPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIR 134

  Fly    91 LSVSGLEDESNYCVLLEMVPIGDCRYKFS--GSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQ 153
            :|.||::.|:.|.||:::||:.:.||:::  .|.|:.||.|:|..|.|:|:|||||.||.....|
Human   135 VSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQ 199

  Fly   154 PILFNKVKLTNNTLDNSGHIVLASMHKYQPRLHVIR----TADLAQIPWAPQQAFVFAETEFVAV 214
            .:.|.|||||||.||..|||:|.||||||||:|:|:    ||.|..:.....:.|:|.||.|.||
Human   200 MVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAV 264

  Fly   215 TAYQNDRITKLKIDNNPFAKGFRETGQSRCKRKMSSSPTGEDQDQSPSLSHSQSQSESDMSPTKG 279
            |||||..|||||||:||||||||:          ||..|..:::...||....|.:.|.:. |.|
Human   265 TAYQNQLITKLKIDSNPFAKGFRD----------SSRLTDIERESVESLIQKHSYARSPIR-TYG 318

  Fly   280 GGETAGGTSSIGDSDGPQIKRLRSNGSACSLSSSLDDQSVPGASSLALGSPPPHLHSHSHPHPLQ 344
            |.|         |..|.:.:...:.|||.:.|.:|...|...:||...|        ..||..|.
Human   319 GEE---------DVLGDESQTTPNRGSAFTTSDNLSLSSWVSSSSSFPG--------FQHPQSLT 366

  Fly   345 ARSASSVFMQHFQQNMQSLLRPSLVDLACTYFGRPHEYGGAIQ-----ASPMYPPA-AMLQAGLG 403
            |...|:.          |:..|.           ||...|::.     ..|:.|.| |....|.|
Human   367 ALGTSTA----------SIATPI-----------PHPIQGSLPPYSRLGMPLTPSAIASSMQGSG 410

  Fly   404 P-HPGLNLP 411
            | .|..::|
Human   411 PTFPSFHMP 419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Doc2NP_648282.1 T-box_Drosocross-like 56..238 CDD:410332 104/192 (54%)
TBX20NP_001071121.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 62..81
T-box_TBX20-like 100..289 CDD:410319 103/198 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..340 9/32 (28%)
P-loop containing Nucleoside Triphosphate Hydrolases <337..>409 CDD:476819 21/100 (21%)
Blue background indicates that the domain is not in the aligned region.

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