DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc2 and mgaa

DIOPT Version :9

Sequence 1:	NP_648282.1	Gene:	Doc2 / 39038	FlyBaseID:	FBgn0035956	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_005158676.1	Gene:	mgaa / 569620	ZFINID:	ZDB-GENE-030603-1	Length:	2838	Species:	Danio rerio

Alignment Length:	523	Identity:	151/523 - (28%)
Similarity:	225/523 - (43%)	Gaps:	139/523 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PRVTLP------GVEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLE 107
            |...||      |:.:||.|:::|.:||:..||||:||.||||||..|..:||:|...||.:.::
Zfish    87 PSENLPADARCRGITVTLDNNNMWNEFHRCKTEMILTKQGRRMFPYCRFRLSGMEPFQNYVLAMD 151

  Fly   108 MVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGH 172
            :.|..:||||:||..|.|.|.|||.. .|:::||:|||:|.||...|:.|.::||. ||||..||
Zfish   152 IKPADNCRYKWSGKGWEPNGKAEPHI-SRLFVHPESPASGLHWMQYPVSFYRLKLC-NTLDQEGH 214

  Fly   173 IVLASMHKYQPRLHVIR----TADLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKIDNNPFA 233
            |:|.|||:|.|::|:|.    :.|:..:.........||:|||.|||||||..||:||||.||||
Zfish   215 IILHSMHRYLPQIHIIPADKVSKDILILDRPNVVTLSFAQTEFFAVTAYQNLCITQLKIDYNPFA 279

  Fly   234 KGFRETG----QSRCKRKMSSSPTGEDQDQSPSL---------------SHSQSQSESDMSPTKG 279
            |||||..    .|:.|..:|:..|..:...|..:               |...:.:::..:||.|
Zfish   280 KGFREDAVNARSSKAKNGLSTDETESELKLSKEMTTLNNLKTLFMKRKASVKVNVNQNVPNPTNG 344

  Fly   280 GGETAGGT-----------------SSIGDSD-----GPQIKRL------RSNG-----SACS-- 309
            ..:...|.                 ||:..||     ..::|||      ::.|     :||:
Zfish   345 ENKVVNGAAPAVDTNVQSLCNKKRPSSLAFSDFIKGAHVKVKRLSLENINKTGGATEPSTACTSK 409

  Fly   310 ------LSS------SLDDQSVPGA----------SSLALGSPPPHLHSHSHPHPLQARSASSVF 352
                  :||      .:|.:...||          :||..|.    |.::.....:...||....
Zfish   410 QKEAADISSITENSLQVDQKDGNGAGDVLRCESTDTSLKTGV----LKANEIKKEIDEHSADKNT 470

  Fly   353 MQHFQQNM--------------------QSLLRPSLVDLACTYFGRPHEYGGAIQASPMYPPAAM 397
            ::...||:                    ::.::.:|          ||:       .|...|..:
Zfish   471 LKSSDQNLSCSDEKKMETVSSLSTEAKPEAQMKKTL----------PHK-------RPERVPLPL 518

  Fly   398 LQAGLGPHPGLNLPPGVSGADLISDESGAEELELDVGSE---------TSTLEQSTQEQPLEQPS 453
            |...|.....: ||..||.:.|...|...|..:....|.         |:.|:.......|.|..
Zfish   519 LAKFLKQRRPI-LPKPVSHSSLSDSEKSCEPAQTSESSSVLMSFVPCVTTNLDSQPAVTSLSQTV 582

  Fly   454 TRS 456
            |.|
Zfish   583 TSS 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	94/194 (48%)
mgaa	XP_005158676.1	T-box	102..284	CDD:279278	91/183 (50%)
		DUF4801	1321..1366	CDD:292677
		NTR2	<2131..2271	CDD:292097
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910