DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doc2 and Mga

DIOPT Version :9

Sequence 1:	NP_648282.1	Gene:	Doc2 / 39038	FlyBaseID:	FBgn0035956	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_006234859.1	Gene:	Mga / 499874	RGDID:	1561597	Length:	3093	Species:	Rattus norvegicus

Alignment Length:	339	Identity:	124/339 - (36%)
Similarity:	181/339 - (53%)	Gaps:	46/339 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VIMPPRVTLPGVEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMV 109
            :.:|...|:..:.:||.|:.:|.:||...||||:||.||||||..|..::||:....|.:::::.
  Rat    64 ICLPADCTVGKITVTLDNNSMWNEFHNRSTEMILTKQGRRMFPYCRYWITGLDSNLKYILVMDIS 128

  Fly   110 PIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGHIV 174
            |:...|||::|..|.|:|.|||....|:::||:||:||.:|..||:.|.|:||||||||..|||:
  Rat   129 PVDSHRYKWNGRWWEPSGKAEPHILGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHII 193

  Fly   175 LASMHKYQPRLHVI---RTADLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKIDNNPFAKGF 236
            |.|||:|.||||::   :..::.|:.......|.|.:|||.|||||||.:||:||||.|||||||
  Rat   194 LHSMHRYLPRLHLVPAEKATEVIQLNGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGF 258

  Fly   237 RETGQSRCKRKMSSSPTGEDQDQSPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQIKRL 301
            |:.|       :||.|      |......:.|..|.               :|:..|.|.:::..
  Rat   259 RDDG-------LSSKP------QRDGKQRNSSDQEG---------------NSVSSSPGHRVRLT 295

  Fly   302 RSNGSACSLSSSLDDQSVPG--ASSLALGSPPPHLH---------SHSHPHPLQARSASSVFMQH 355
            ...||  .:.|...|..:.|  .|||.|...|.::.         ..:|..|...|..|...:..
  Rat   296 EGEGS--EIHSGDFDPVLRGHETSSLGLEKAPNNVKQDFLGFMNTDSTHEVPQLKREISESHVSS 358

  Fly   356 FQQNMQ--SLLRPS 367
            |::|.|  |.|.|:
  Rat   359 FEENSQISSPLNPN 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	93/189 (49%)
Mga	XP_006234859.1	T-box_MGA-like	75..260	CDD:410321	91/184 (49%)
		DUF4801	1040..1081	CDD:406462
		Herpes_BLLF1	<1519..1828	CDD:282904
		Atrophin-1	1692..>2024	CDD:397323
		bHLHzip_MGA	2454..2518	CDD:381481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910