Protein Alignment Doc2 and Tbx21

DIOPT Version :10

• Sequence 1: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001100513.1
• Gene: Tbx21 / 303496
• RGDID: 1308264
• Length: 528
• Species: Rattus norvegicus
• Alignment Length: 477
• Identity: 158/477 - (33%)
• Similarity: 215/477 - (45%)
• Gaps: 113/477 - (23%)

  Fly    27 QRIPDP-----FPPM--LPIPMPRHVIMP-PR--VTLP-GVEMT------LQNDDLWKQFHQIGT 74
            :..|.|     :||:  ...|.||..:.| ||  ..|| |:|::      |.|..||.:|:|..|
  Rat    90 ESFPPPAGAEGYPPVDGYAAPDPRAGLYPGPREDYALPAGLEVSGKLRVALSNHLLWSKFNQHQT 154

  Fly    75 EMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSP-QRMY 138
            ||||||.||||||.:..:|:|||..|:|.:.:::|.:....:::...:||..|.||...| .|:|
  Rat   155 EMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLY 219

  Fly   139 LHPDSPATGAHWQAQPILFNKVKLTNN---TLDNSGHIVLASMHKYQPRLHVIRTADLAQIPWAP 200
            :|||||.|||||..|.:.|.|:|||||   :.:.:..|||.|:||||||||::...|     ..|
  Rat   220 VHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVND-----GEP 279

  Fly   201 QQA-------FVFAETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRCKRKMSSSPTGEDQD 258
            :.|       |.|.||:|:|||||||..||:||||||||||||||..:|......:|.|
  Rat   280 EAACSANTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSVP------ 338

  Fly   259 QSPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQIKRLRSNGSACSLSSSLDDQSVPG-- 321
                            ||.....:..|     ||...|    |.||....|.....|   :||
  Rat   339 ----------------SPPGPNCQLLG-----GDPYSP----LLSNQYPVSSRFYPD---LPGQP 375

  Fly   322 ----ASSLALGSPPPHLHSHSHPHPLQARSASSVFMQHFQQNMQSLLRPSLVDLACTYFGRPHEY 382
                :.|..||:|    ...|:....:|.|....|:            ||.......|:..|...
  Rat   376 KDMVSQSYWLGTP----REPSYETEFRAVSVKPTFL------------PSAPGTTVPYYRGPDVL 424

  Fly   383 --GGAIQASPMYPPAAMLQAG-------LGPHPGLNLPPGVSGADLISDESGAEELELDVGSETS 438
              |.....:|.||| .|..||       |...|||.          .|:|.|:..|    .:|.:
  Rat   425 APGAGWPMAPQYPP-KMSPAGWFRTMRTLPMDPGLG----------SSEEQGSPSL----WTEVT 474

  Fly   439 TLEQSTQEQPLEQPSTRSKGFS 460
            :|:....:..|.:..|:.:..|
  Rat   475 SLQPEPSDSGLGEGDTKRRRIS 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	T-box_Drosocross-like	56..238	CDD:410332	94/198 (47%)
Tbx21	NP_001100513.1	T-box_TBX21	135..324	CDD:410329	93/193 (48%)
		T-box_assoc	<392..518	CDD:465042	29/132 (22%)