DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc2 and Tbx4

DIOPT Version :9

Sequence 1:	NP_648282.1	Gene:	Doc2 / 39038	FlyBaseID:	FBgn0035956	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_006247098.1	Gene:	Tbx4 / 303399	RGDID:	1309057	Length:	555	Species:	Rattus norvegicus

Alignment Length:	424	Identity:	151/424 - (35%)
Similarity:	213/424 - (50%)	Gaps:	68/424 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TLPGVEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGDCRY 116
            |:..:::.|...:|||:||:.||||||||:|||||||.::.|:|:..::.|.:|:::||..|.||
  Rat    71 TIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRY 135

  Fly   117 KFSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGHIVLASMHKY 181
            ||..::|:.||.|||..|.|:|:|||||||||||..|.:.|.|:|||||.||..|||:|.|||||
  Rat   136 KFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKY 200

  Fly   182 QPRLHVIRTADLAQIPWAPQQAF---VFAETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQS- 242
            |||||::: ||......:...||   ||.||.|::||:|||.:||:|||:|||||||||.:..|
  Rat   201 QPRLHIVK-ADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSD 264

  Fly   243 -RCKRKMSSS-PTGEDQDQSPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQIKRLRSNG 305
             |..|..|.. |..........|..||..::.|:||.              .|....::..:...
  Rat   265 LRVARLQSKEYPVISKSIMRQRLVSSQLSAKPDVSPL--------------HSTHQALQHYQYEN 315

  Fly   306 SACSLSSSLDDQSVPGASSLALGSPPPHLHSHSHPHPLQARSASSVFMQHFQQNMQSLLRPSLVD 370
            .|....::.:.|.:|      |.:.|....|....|.|:.|:.|:   :|             :|
  Rat   316 GAHMQFAAAEPQDLP------LNTFPTQRDSSLFYHCLKRRADSA---RH-------------LD 358

  Fly   371 LACT--------------YFGRPHEYGGAIQASPMY-----PPAAMLQAGLGPHPGLNLPPGVSG 416
            |.|.              ||..|..|...: .||.|     |..|.:.:..||...     |||.
  Rat   359 LPCKRSYLETPSSVGDDHYFRSPPPYDQQM-LSPSYCSEVTPREACMYSSSGPEIA-----GVSA 417

  Fly   417 ADLISDESGAEELELDVGSETSTLEQSTQEQPLE 450
            .|.:.....:..:...|...||...|:.:..|.:
  Rat   418 VDDLPPPPLSCNMWTSVSPYTSYSVQTMETVPYQ 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	104/189 (55%)
Tbx4	XP_006247098.1	TBOX	74..263	CDD:238106	104/189 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910