DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doc2 and tbx2b

DIOPT Version :9

Sequence 1:	NP_648282.1	Gene:	Doc2 / 39038	FlyBaseID:	FBgn0035956	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_571126.1	Gene:	tbx2b / 30253	ZFINID:	ZDB-GENE-990726-27	Length:	687	Species:	Danio rerio

Alignment Length:	546	Identity:	183/546 - (33%)
Similarity:	261/546 - (47%)	Gaps:	137/546 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PDPFPPM------LPIPMPRHVI-------MPPRV----------TLPGVE----------MTLQ 61
            |..||.:      |..|:|.|.:       :.|.:          :|..:|          :||:
Zfish    35 PSFFPALTLPPGALTKPIPDHTLAGAAEAGLHPALSHHHQAAHLRSLKSLEPEEEVEDDPKVTLE 99

  Fly    62 NDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGDCRYKFSGSQWVPA 126
            ..|||.|||::||||:||||||||||..::.::||:.::.|.:|:::|...||||||..|:|:.|
Zfish   100 AKDLWDQFHKLGTEMVITKSGRRMFPPFKVRINGLDKKAKYILLMDIVAADDCRYKFHNSRWMVA 164

  Fly   127 GGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGHIVLASMHKYQPRLHVIRTA 191
            |.|:|:.|:|||:||||||||..|.|:|:.|:|:|||||..|..|..:|.||||||||.|::|..
Zfish   165 GKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRAN 229

  Fly   192 DLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRC-KRKMSSSPT-- 253
            |:.::|::..:.:||.||:|:||||||||:||:|||||||||||||:||..|. |||..:.|:
Zfish   230 DILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLR 294

  Fly   254 -----------GEDQDQSPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQIKRLRSN-GS 306
                       |.|.|.|.|            .||.|        ...|.|.||....||.| ||
Zfish   295 MYEDQCKVDRDGADSDASSS------------EPTTG--------RDAGHSPGPVSSPLRFNRGS 339

  Fly   307 ----ACSLSS-SLDDQSVP-GASSLALGSPPPHLHSHSH-------------PHPLQARSASSVF 352
                .|:.|. .:|.|:.. |.||.....|.....|.|.             .:|...:::.|:|
Zfish   340 RDDKTCTDSEHEMDHQNDRCGGSSSPAPKPSSPFRSRSEDWGREKPIAEKKDDYPDSRKTSDSIF 404

  Fly   353 -MQHFQQN-MQSLLR-----------------------PSLVDL-ACTYFGRPHEYG---GAIQA 388
             :::.::: ::|..|                       |.:|.. :.::||..|...   ..:.:
Zfish   405 SIRNLEKDKLESRSRKDTDSSKKDTENSGISGSKDSFSPLMVQTESPSHFGAGHLQSLALSGLHS 469

  Fly   389 SPMYPPAAMLQAG--LGPHPG-LNLPPGVSGA----DLISDESGAEELELDVGSETSTLEQSTQE 446
            ...:.|   |..|  |..||| ..:.||...|    .|::..|||..||     ..|...|.|..
Zfish   470 QQFFNP---LNTGQPLLFHPGQFAMAPGAFSAMGMGHLLASVSGAGGLE-----NGSLSAQGTGS 526

  Fly   447 QP------LEQPSTRSKGFSISAILG 466
            .|      |.|....|:|..:....|
Zfish   527 TPSPFPFHLSQHMLASQGIPMPTFGG 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	107/196 (55%)
tbx2b	NP_571126.1	TBOX	95..278	CDD:238106	104/182 (57%)
		TBX	294..361	CDD:204975	21/86 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..452		34/168 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810