DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc2 and Tbx6

DIOPT Version :9

Sequence 1:	NP_648282.1	Gene:	Doc2 / 39038	FlyBaseID:	FBgn0035956	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_035668.2	Gene:	Tbx6 / 21389	MGIID:	102539	Length:	436	Species:	Mus musculus

Alignment Length:	420	Identity:	169/420 - (40%)
Similarity:	229/420 - (54%)	Gaps:	71/420 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PMLPIPM-PRHVIMPPRV--TLPGVEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGL 96
            |:||..: |.....||..  :||||.::|:|.:|||:|..:||||||||:||||||:.|:||:||
Mouse    67 PLLPSALGPETAPPPPEALHSLPGVSLSLENQELWKEFSAVGTEMIITKAGRRMFPACRVSVTGL 131

  Fly    97 EDESNYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVK 161
            :.|:.|..||::||:...||::.|..|.|:|.|||:.|.|:|:|||||||||||..||:.|::||
Mouse   132 DPEARYLFLLDVVPVDGARYRWQGQHWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVK 196

  Fly   162 LTNNTLDNSGHIVLASMHKYQPRLHVIRTADLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLK 226
            |||:|||..||::|.||||||||:|::|...|....|....:|.|.||.|::||||||.|||:||
Mouse   197 LTNSTLDPHGHLILHSMHKYQPRIHLVRATQLCSQHWGGVASFRFPETTFISVTAYQNPRITQLK 261

  Fly   227 IDNNPFAKGFRETGQSRCKRKMSSSPTGEDQDQSPSLSHSQSQSESDMSPTKGGGETAGG--TSS 289
            |..|||||||||.|:: |||:..:....:.:...|..:.:           .|.|:|.||  .|:
Mouse   262 IAANPFAKGFRENGRN-CKRERDARVKRKLRGPEPVATEA-----------CGSGDTPGGPCDST 314

  Fly   290 IG----DSDGPQIKRLRSNGSACSLSSSLDDQSVPGASSLALGSPPPH---LHS---HSHPHPLQ 344
            :|    |||..|               :...|....||:...|.|...   ||.   |..|..|.
Mouse   315 LGGDIRDSDPEQ---------------APTPQEAASASAPPCGGPSAEAYLLHPAAFHGAPSHLP 364

  Fly   345 ARSASSVFMQHFQQNMQSLLRPSLVDLACTYFGRPHEYGGAIQASPMYPPAA--MLQAGLGPHPG 407
            ||:.|  |.:.......:....:.:||      :|...|.|.||:|..|..|  .:|.  ||.|
Mouse   365 ARTPS--FAEAPDPGRPAPYSAAFLDL------QPGPGGSAYQAAPSVPSFAPHFIQG--GPFP- 418

  Fly   408 LNLP-PGVSGADLISDESGAEELELDVGSE 436
              || ||..|             .||:||:
Mouse   419 --LPYPGPGG-------------YLDMGSK 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	109/186 (59%)
Tbx6	NP_035668.2	TBOX	90..277	CDD:238106	109/186 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831461
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3037
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003805
OrthoInspector	1	1.000	-	-		otm43723
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6331
SonicParanoid	1	1.000	-	-		X4271
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.880