Protein Alignment Doc2 and Tbx2

DIOPT Version :9

• Sequence 1: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_033350.2
• Gene: Tbx2 / 21385
• MGIID: 98494
• Length: 711
• Species: Mus musculus
• Alignment Length: 553
• Identity: 175/553 - (31%)
• Similarity: 247/553 - (44%)
• Gaps: 146/553 - (26%)

  Fly    57 EMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGDCRYKFSGS 121
            ::||:..:||.|||::||||:||||||||||..::.||||:.::.|.:|:::|...||||||..|
Mouse   106 KVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNS 170

  Fly   122 QWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGHIVLASMHKYQPRLH 186
            :|:.||.|:|:.|:|||:||||||||..|.|:|:.|:|:|||||..|..|..:|.||||||||.|
Mouse   171 RWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFH 235

  Fly   187 VIRTADLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSR-------- 243
            ::|..|:.::|::..:.:||.||:|:||||||||:||:|||||||||||||:||..|
Mouse   236 IVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLT 300

  Fly   244 ----------CK------------------RKMSSSP---------------------------- 252
                      ||                  |:...||
Mouse   301 LPTLRLYEEHCKPERDGAESDASSCDPPPAREPPPSPSAAPSPLRLHRARAEEKPGAADSDPEPE 365

  Fly   253 -TGEDQDQSPSLSHSQSQSES-------------------DMSPTKGGGETAGGTSSIGDSDGPQ 297
             |||::..:| |..|.|:..|                   ...||:|||:......|: :.:.|:
Mouse   366 RTGEERSAAP-LGRSPSRDASPARLTEPERSRERRSPERCSKEPTEGGGDGPFSLRSL-EKERPE 428

  Fly   298 IKRLRSNG----------SACSLSSSLDDQSVPGAS---SLALGSPPPHLHSHSHPHPLQARSAS 349
            .:| :..|          |...|....|..|..||.   .||..|   |||......||.|....
Mouse   429 ARR-KDEGRKDVGEGKEPSLAPLVVQTDSASPLGAGHLPGLAFSS---HLHGQQFFGPLGAGQPL 489

  Fly   350 SVFMQHFQQNMQSLLRPSLVDLACTYFGRPHEYGGA-------IQASPMYPPAA----------- 396
            .:....|.....:.....:..|..:..|.....|||       :.|..:.|.|:
Mouse   490 FLHPGQFAMGPGAFSAMGMGHLLASVAGGSGSSGGAGPGTAAGLDAGGLGPAASAASTAAPFPFH 554

  Fly   397 ----MLQA---------GLGPHP---------GLNLPPGVSGADLISDESGAEELELDVGSETST 439
                ||.:         ||.|:|         ..:..|..|.|...:..:|:......:||....
Mouse   555 LSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPR 619

  Fly   440 LEQSTQEQPLEQPSTRS---KGFSISAILGGGS 469
            |..|..:.|:..|.:.|   .|.:.....||.|
Mouse   620 LRFSPYQIPVTIPPSTSLLTTGLAAEGSKGGNS 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	107/184 (58%)
Tbx2	NP_033350.2	TBOX	104..289	CDD:238106	105/182 (58%)
		TBX	305..382	CDD:204975	11/77 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..449		21/138 (15%)
		Repression domain 1 (RD1). /evidence=ECO:0000250	518..602		15/83 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..687		4/13 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810