Protein Alignment Doc2 and tbx6

DIOPT Version :9

• Sequence 1: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_705952.2
• Gene: tbx6 / 192294
• ZFINID: ZDB-GENE-020416-5
• Length: 874
• Species: Danio rerio
• Alignment Length: 550
• Identity: 179/550 - (32%)
• Similarity: 245/550 - (44%)
• Gaps: 140/550 - (25%)

  Fly    27 QRIPD--------PFPP----MLPIPMPRHVIMP------PRVTLPGVEMTLQNDDLWKQFHQIG 73
            ||:.|        |..|    |....:|..::.|      |......|.|.|:|..|||||..:|
Zfish    15 QRLSDCYYRDRDVPLYPSTCEMAARALPPALLKPHANTDSPATPQDSVRMELENAGLWKQFSTVG 79

  Fly    74 TEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMY 138
            ||||:||.||||||.:|:.:|||.....|.:||::||:...||:|..:.|...||||.:.|.|::
Zfish    80 TEMIVTKKGRRMFPQLRVKLSGLNPSLRYILLLDIVPVDSSRYRFQDNSWQVVGGAEARLPDRVF 144

  Fly   139 LHPDSPATGAHWQAQPILFNKVKLTNNTLDNSGHIVLASMHKYQPRLHVIRTADLAQIPWA-PQQ 202
            :||||||||.|||.:.|.|::.||||||||..|:|:|.|:|:||||:|||...|:  :.|. .|.
Zfish   145 IHPDSPATGEHWQNRTISFHRAKLTNNTLDAQGYIILHSLHRYQPRVHVIEARDV--LMWGRTQH 207

  Fly   203 AFVFAETEFVAVTAYQNDRITKLKIDNNPFAKGFRETG-------QSRCKRKMSSS--------- 251
            :|.|.||:|:.||||||::||:|||::|||||||||.|       ::|.|||::||
Zfish   208 SFTFPETQFITVTAYQNNKITELKINSNPFAKGFRENGMNCKKQREARLKRKITSSQEECLDIES 272

  Fly   252 ------------------------------------------PTGEDQDQS------------PS 262
                                                      |...|.||:            ||
Zfish   273 CDPCDSTELLPQSVDLPSSALTIMNTALPITDSGFHTEVSSHPDQTDSDQTLVLEQAFLTSEMPS 337

  Fly   263 LSHSQSQSESD-------MSPTKGGGETAGGTSSIGDSDGPQIKRLRSNGSACSL-----SSSLD 315
            ...||.|:.|:       |..|....:.:|.|||.   ..||:....|...:.|:     |:...
Zfish   338 SMESQQQTTSETNVNNALMDETGQMMDLSGYTSSF---PTPQLSSHTSVPQSSSMYSVVSSTQSS 399

  Fly   316 DQSVPGASSLALGSPPPHLHSHSHPHPLQARSASSVFMQHFQQNMQSLLRPSLVDLACTYFGRPH 380
            |..:|.|||:            |.||.:.|.| |....::...|..:.:..|...|:.:|....|
Zfish   400 DLELPQASSI------------SSPHSMPAYS-SIPSAEYPGVNSSTAMPASTTSLSDSYPSISH 451

  Fly   381 EYGGAIQASPMYP---PAAMLQAGLGPHPGLNLP----PGVSGADLISDESGAEELELDVG---- 434
            .....:..|..|.   |....|..|.||...|.|    |...|..|..| ||..::: |.|
Zfish   452 STSSHLLQSSSYHSLLPTDQSQDNLSPHTPTNPPFQSIPACQGTRLTID-SGQNQVD-DGGLSSA 514

  Fly   435 -SETSTLEQSTQE-------QPLEQPSTRS 456
             :.|..:...||.       ||...|...|
Zfish   515 NATTPAVPNPTQTAFPFPPVQPNNDPDPTS 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	103/194 (53%)
tbx6	NP_705952.2	TBOX	62..247	CDD:238106	103/186 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..396		8/34 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..453		5/24 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..551		21/80 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	563..626
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	664..695
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	720..776

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574470
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6331
SonicParanoid	1	1.000	-	-		X4271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.830