DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doc2 and TBR1

DIOPT Version :9

Sequence 1:	NP_648282.1	Gene:	Doc2 / 39038	FlyBaseID:	FBgn0035956	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_006584.1	Gene:	TBR1 / 10716	HGNCID:	11590	Length:	682	Species:	Homo sapiens

Alignment Length:	489	Identity:	158/489 - (32%)
Similarity:	222/489 - (45%)	Gaps:	99/489 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TLPGV-----EMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPI 111
            |.||:     ::.|.|..||.:||:..|||||||.||||||.:..::|||:..::|.:.::::..
Human   195 TQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILA 259

  Fly   112 GDCRYKFSGSQWVPAGGAEPQ-SPQRMYLHPDSPATGAHWQAQPILFNKVKLTNN--TLDNSGH- 172
            ....::|.|.:|||.|.|:.. ...|:|:|||||.|||||..|.|.|.|:|||||  ..:|:|.
Human   260 DPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQM 324

  Fly   173 IVLASMHKYQPRLHVIR-----TADLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKIDNNPF 232
            :||.|:|||||||||:.     |.|.:| | ...|.|.|.||:|:|||||||..||:||||:|||
Human   325 VVLQSLHKYQPRLHVVEVNEDGTEDTSQ-P-GRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPF 387

  Fly   233 AKGFRETGQSRCKRKMSSSPTGEDQDQSPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQ 297
            |||||:        ...:..||.|.|:.     :.|.::|..|....|...|...|.:.|.....
Human   388 AKGFRD--------NYDTIYTGCDMDRL-----TPSPNDSPRSQIVPGARYAMAGSFLQDQFVSN 439

  Fly   298 IKRLRSNGSACSLSSSLDDQSVPGASSLALGSPPPHLHSHSHPHPLQ------------ARSASS 350
            ..:.|.:..|.:......|:|||..:.|.   .|........|.|.:            |.||..
Human   440 YAKARFHPGAGAGPGPGTDRSVPHTNGLL---SPQQAEDPGAPSPQRWFVTPANNRLDFAASAYD 501

  Fly   351 VFMQHFQQNMQSLLRPS--------LVDLACTYFGRPHEY-----GGAIQASPMY---------- 392
            . ...|..|..:||..:        |....||  |||..|     |...::.|.|
Human   502 T-ATDFAGNAATLLSYAAAGVKALPLQAAGCT--GRPLGYYADPSGWGARSPPQYCGTKSGSVLP 563

  Fly   393 -----PPAAMLQAGLGPHPGLN----------LPPG---------VSGADLISDESGAEELELDV 433
                 ..||...||..|:.|..          ||||         :|.:..|...|..:.::
Human   564 CWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGAAEDAKPKDLSDSSWIETPSSIKSID--- 625

  Fly   434 GSETSTLEQSTQEQ--PLEQPSTRSKGFSISAIL 465
            .|::...||:.:.:  |.:.|.:.|.....|.:|
Human   626 SSDSGIYEQAKRRRISPADTPVSESSSPLKSEVL 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	97/200 (49%)
TBR1	NP_006584.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..83
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127
		T-box_TBR1	203..393	CDD:410330	95/191 (50%)
		T-box_assoc	418..680	CDD:406561	52/251 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..483		9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..658		14/72 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910