Protein Alignment Doc2 and eomes

DIOPT Version :10

• Sequence 1: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001122124.1
• Gene: eomes / 100038065
• XenbaseID: XB-GENE-479769
• Length: 667
• Species: Xenopus tropicalis
• Alignment Length: 533
• Identity: 167/533 - (31%)
• Similarity: 229/533 - (42%)
• Gaps: 143/533 - (26%)

  Fly    14 QHIAHEIYRQQIMQRIPDPFPPMLP-----------------------IPMPRHVIMPPRVT--- 52
            ||.|  :|......|.| |:..|||                       .|...:...||..|
 Frog   153 QHSA--VYPAGGAARYP-PYGSMLPPAGFSPPVCPSRPQYSSGYQYSQAPGTMYSPYPPAGTGSG 214

  Fly    53 -----LPG------VEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLL 106
                 |||      .::.|.|..||.:||:..|||||||.||||||.:..:::||...::|.|.:
 Frog   215 LSALGLPGGGAGVRAQVFLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNITGLNPTAHYNVFV 279

  Fly   107 EMVPIGDCRYKFSGSQWVPAGGAE-PQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNNTLDNS 170
            |:|......::|.|.:||..|.|: .....::|:||:||.|||||..|.|.|.|:|||||...|:
 Frog   280 EVVLADPNHWRFQGGKWVTCGKADNNMQGNKVYVHPESPNTGAHWMRQEISFGKLKLTNNKGANN 344

  Fly   171 GH---IVLASMHKYQPRLHVIRTA-----DLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKI 227
            ..   |||.|:||||||||::..:     ||...  |..|.|.|.||:|:|||||||..||:|||
 Frog   345 NSTQMIVLQSLHKYQPRLHIVEVSEDGVEDLNDS--AKSQTFTFPETQFIAVTAYQNTDITQLKI 407

  Fly   228 DNNPFAKGFRETGQSRCKRKMSS--SPTGEDQDQS----PSLSHS-----QSQSESDMSPTK--G 279
            |:||||||||:...|......|.  :|:..|..:|    |...:|     |.|..:::.|.:  .
 Frog   408 DHNPFAKGFRDNYDSMYTASESDRLTPSPADSPRSHQIVPGTRYSVQPFFQDQFVNNLPPARYYS 472

  Fly   280 GGETAGGTSSIGDSDGPQIKRLRSNGSACSLSSSLDDQSVPGASSLALGSPPPHLHSHSHPHPLQ 344
            |..|.           ||     :||   .||...:|:         :.:.||   ......|:|
 Frog   473 GERTV-----------PQ-----ANG---LLSPQTNDE---------VANAPP---QRWFVTPVQ 506

  Fly   345 ARSASSVFMQHFQQNMQ--SLLRPSLVDLACTYFGRPHEYGGAIQAS-PM--YPPAAML-QAGLG 403
            ..:|:.:.|..::.:..  |||...:..|             .||.| ||  ||.||.. .||.|
 Frog   507 QAAANKLDMGAYETDYSSGSLLTYGIKSL-------------PIQTSHPMAYYPDAAFASMAGWG 558

  Fly   404 --------------PHPGLNLPPGVSGADLISDESGAEELELDVGSETSTLEQSTQEQPLEQPST 454
                          |....:.|.|.| .||:..:...||           :..|..|.|   ||.
 Frog   559 SRGSTYQRKMTTTLPWSSRSSPSGFS-EDLLPKDKVKEE-----------MSSSWVETP---PSI 608

  Fly   455 RSKGFSISAILGG 467
            :|...:.|.:..|
 Frog   609 KSLDSNDSGVYTG 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc2	NP_648282.1	T-box_Drosocross-like	56..238	CDD:410332	92/190 (48%)
eomes	NP_001122124.1	T-box_TBR2	228..418	CDD:410331	92/191 (48%)
		T-box_assoc	444..665	CDD:465042	52/237 (22%)