Protein Alignment Doc3 and TBX4

DIOPT Version :9

• Sequence 1: NP_648280.1
• Gene: Doc3 / 39036
• FlyBaseID: FBgn0035954
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: XP_011523792.1
• Gene: TBX4 / 9496
• HGNCID: 11603
• Length: 609
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 159/496 - (32%)
• Similarity: 221/496 - (44%)
• Gaps: 131/496 - (26%)

  Fly    28 RLPDPLCG------------LLPNFAGHFMPPPPPP----------QPTLPGDVEAKLENNELWQ 70
            |.|.|..|            ..|..:|..:..||.|          :.|:. :::..|...|||:
Human    78 RAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIE-NIKVGLHEKELWK 141

  Fly    71 QFHSIGTEMIITKCGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQ 135
            :||..||||||||.|||||||.:|.::|:..:..|.:|:::||..|.||||..::|:.||.|||.
Human   142 KFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPA 206

  Fly   136 SPQRMYLHPESPATGKHWQSQALLFSKVKLTNNTLDNNGHIVLASMHKYQPRLHVIRTSDLGQIP 200
            .|.|:|:||:|||||.||..|.:.|.|:|||||.||..|||:|.||||||||||::: :|.....
Human   207 MPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVK-ADENNAF 270

  Fly   201 WAPQQAF---IFPETEFIAVTAYQNDRITKLKIDNNPFAKGFRESGQS-----RCKRK----IND 253
            .:...||   :||||.||:||:|||.:||:|||:|||||||||.|..|     |.:.|    |:.
Human   271 GSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVISK 335

  Fly   254 SPPPTQPEANQVDRSPVTSPLAKRLRLVEEFPQHHHHQS-------------------------- 292
            |....:..:.|:..:|...||..    ..:..||:.|::
Human   336 SIMRQRLISPQLSATPDVGPLLG----THQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLF 396

  Fly   293 ------------HHSVPMQRHYL--LDALEANFYVPAPPPPAIEYARHIGGAYPSWAYTPPSPAS 343
                        |..:|.:|.||  ..::..:.|..:|||    |.:.:         ..||..|
Human   397 YHCLKRRADGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPP----YDQQM---------LSPSYCS 448

  Fly   344 SVSSSSAGSTSGESAADREADADADTFVDVVGTAPAAPPP-----------------------PS 385
            .|:...|...||          .......|.|.....|||                       |.
Human   449 EVTPREACMYSG----------SGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTSYSVQTMETVPY 503

  Fly   386 PPVPATATAPASSSSDPTMA-----KPKRSSFSISDILGTS 421
            .|.|...||.......||::     .|..:.||:.:.|..|
Human   504 QPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQS 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	TBOX	58..245	CDD:238106	103/189 (54%)
TBX4	XP_011523792.1	TBOX	129..318	CDD:238106	103/189 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910