DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc3 and TBX18

DIOPT Version :9

Sequence 1:	NP_648280.1	Gene:	Doc3 / 39036	FlyBaseID:	FBgn0035954	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001073977.1	Gene:	TBX18 / 9096	HGNCID:	11595	Length:	607	Species:	Homo sapiens

Alignment Length:	447	Identity:	155/447 - (34%)
Similarity:	210/447 - (46%)	Gaps:	84/447 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PPPPPPQPTLPGDVEAKLENNELWQQFHSIGTEMIITKCGRRMFPSMRVSLSGLEEEASYCVLLE 110
            |..|.|.|..|   ...|:..|||::||.|||||||||.||||||:|||.:|||:....|.:.::
Human   129 PGTPLPSPQAP---RVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMD 190

  Fly   111 MVPIGDCRYK--FSGSQWVPAGGAEPQSPQRMYLHPESPATGKHWQSQALLFSKVKLTNNTLDNN 173
            :||:.:.||:  :..|:|:.||.|:...|.|:|:||:|||:|:.|..|.:.|.|:|||||.||:.
Human   191 IVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQ 255

  Fly   174 GHIVLASMHKYQPRLHVIRT---SDLGQIPWAPQ----QAFIFPETEFIAVTAYQNDRITKLKID 231
            |||:|.||||||||:||||.   .||..|...|.    :||.||||.|..||||||.:||:||||
Human   256 GHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKID 320

  Fly   232 NNPFAKGFRESGQSR---------------CKRKINDSPPPTQPEANQVDRSPVTSPLAKRLRLV 281
            .||||||||:||::|               ..|.:.....|..|:......|.:.......:
Human   321 RNPFAKGFRDSGRNRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNASSSTLLQGTGNGV--- 382

  Fly   282 EEFPQHHHH---------QSHHSVPMQRHYLLDALEANFYVPAPPPPAI-EYARHIGGAY----- 331
               |..|.|         .:.|..| ....|.....|::...|.....: .|:..:...|
Human   383 ---PATHPHLLSGSSCSSPAFHLGP-NTSQLCSLAPADYSACARSGLTLNRYSTSLAETYNRLTN 443

  Fly   332 -PSWAYTPPSPASSVSSSSAGSTSGESAADREADADADTF--------VDVVGTAPAAP-PPPSP 386
             ....:.||...|.|..||:.|.:.....     .|.|||        :.:.|.:|... ..|||
Human   444 QAGETFAPPRTPSYVGVSSSTSVNMSMGG-----TDGDTFSCPQTSLSMQISGMSPQLQYIMPSP 503

  Fly   387 PVPATAT--------------APAS------SSSDPTMAKPKRSSFSISDILGTSSS 423
            ...|.||              :|.:      |:|....|.|::...|....||:|.|
Human   504 SSNAFATNQTHQGSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSSPS 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	TBOX	58..245	CDD:238106	106/195 (54%)
TBX18	NP_001073977.1	Engrailed homology 1 repressor. /evidence=ECO:0000305	18..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..141		5/14 (36%)
		Nuclear localization signal. /evidence=ECO:0000305	36..40
		TBOX	139..334	CDD:238106	107/197 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910