DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doc3 and TBX3

DIOPT Version :9

Sequence 1:	NP_648280.1	Gene:	Doc3 / 39036	FlyBaseID:	FBgn0035954	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_057653.3	Gene:	TBX3 / 6926	HGNCID:	11602	Length:	743	Species:	Homo sapiens

Alignment Length:	451	Identity:	156/451 - (34%)
Similarity:	220/451 - (48%)	Gaps:	88/451 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTLP--NIADLRLQQQIAQEIYRQQI-MQRLPDPLCGLLPNFAGHFMP-PPPPPQPTLPGDVEAK 62
            ||||  ..|.|.|...:|:.|..|.: ......|...|.|.  .|..| ....|:..:..|.:..
Human    44 LTLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQ--AHLRPLKTMEPEEEVEDDPKVH 106

  Fly    63 LENNELWQQFHSIGTEMIITKCGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWV 127
            ||..|||.|||..||||:|||.||||||..:|..|||:::|.|.:|::::...||||||..|:|:
Human   107 LEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWM 171

  Fly   128 PAGGAEPQSPQRMYLHPESPATGKHWQSQALLFSKVKLTNNTLDNNG------------------ 174
            .||.|:|:.|:|||:||:|||||:.|.|:.:.|.|:|||||..|.:|
Human   172 VAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSF 236

  Fly   175 --HIVLASMHKYQPRLHVIRTSDLGQIPWAPQQAFIFPETEFIAVTAYQNDRITKLKIDNNPFAK 237
              ..:|.||||||||.|::|.:|:.::|::..:.::|||||||||||||||:||:||||||||||
Human   237 GTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAK 301

  Fly   238 GFRESGQSRCKRKINDSPPPTQPEANQVDRSPVTSPLAKRLRLVEEFPQHHHHQSHHSVPMQRHY 302
            |||::|..|.::                 |..:|   .:.:|:.:|..:..:..|..|...|..:
Human   302 GFRDTGNGRREK-----------------RKQLT---LQSMRVFDERHKKENGTSDESSSEQAAF 346

  Fly   303 LLDALEANFYVPAPPPPAIEYARHIGGAYPSWAYTPPSPASSVSSS-------SAGSTSGESAAD 360
                   |.:..|..|                      .||:|.:|       |.|.:..|:.:.
Human   347 -------NCFAQASSP----------------------AASTVGTSNLKDLCPSEGESDAEAESK 382

  Fly   361 READADADTFVDVVGTAPAAP--PPPSPPVPA---TATAPASSSS-DPTMAKPKRSSFSIS 415
            .|...:|.....:..|....|  ...||.|.|   .|..|..|.. |......:.|..:||
Human   383 EEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAERPRDSGRLDKASPDSRHSPATIS 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	TBOX	58..245	CDD:238106	107/206 (52%)
TBX3	NP_057653.3	TBOX	104..307	CDD:238106	105/202 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..342		12/60 (20%)
		TBX	323..411	CDD:204975	20/116 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..465		22/87 (25%)
		Transcription repression	544..695
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..707
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810