Protein Alignment Doc3 and TBX2

DIOPT Version :9

• Sequence 1: NP_648280.1
• Gene: Doc3 / 39036
• FlyBaseID: FBgn0035954
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_005985.3
• Gene: TBX2 / 6909
• HGNCID: 11597
• Length: 712
• Species: Homo sapiens
• Alignment Length: 405
• Identity: 153/405 - (37%)
• Similarity: 217/405 - (53%)
• Gaps: 78/405 - (19%)

  Fly    29 LPDP-LCGLLPNFAG---------HF--MPPPPP-----------PQPTLPGDVEAKLENNELWQ 70
            |||| |.|.....|.         |.  :.|.||           |:..:..|.:..||..|||.
Human    52 LPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWD 116

  Fly    71 QFHSIGTEMIITKCGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQ 135
            |||.:||||:|||.||||||..:|.:|||:::|.|.:|:::|...||||||..|:|:.||.|:|:
Human   117 QFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPE 181

  Fly   136 SPQRMYLHPESPATGKHWQSQALLFSKVKLTNNTLDNNGHIVLASMHKYQPRLHVIRTSDLGQIP 200
            .|:|||:||:|||||:.|.::.:.|.|:|||||..|.:|..:|.||||||||.|::|.:|:.::|
Human   182 MPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLP 246

  Fly   201 WAPQQAFIFPETEFIAVTAYQNDRITKLKIDNNPFAKGFRESGQSRCKRKINDSPPPTQPEANQV 265
            ::..:.::||||:||||||||||:||:|||||||||||||::|..|.::
Human   247 YSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREK---------------- 295

  Fly   266 DRSPVTSPLAKRLRLVEEFPQHHHHQSHHSVPMQRHYLLDALEANFYVPAPPPPAIEYARHIGGA 330
             |..:|.|   .|||.||          |..|.:.....||...:      ||||.|
Human   296 -RKQLTLP---SLRLYEE----------HCKPERDGAESDASSCD------PPPARE-------- 332

  Fly   331 YPSWAYTPPSPASSVSSSSAGSTSGESAADREADADADTFVDVVGTAPAAPPPPSPPVPATATAP 395
                  .|.||.::.|.........|   ::...||:|...:.:....|..|....|.|.:|:
Human   333 ------PPTSPGAAPSPLRLHRARAE---EKSCAADSDPEPERLSEERAGAPLGRSPAPDSAS-- 386

  Fly   396 ASSSSDPTMAKPKRS 410
            .:..::|..|:.:||
Human   387 PTRLTEPERARERRS 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	TBOX	58..245	CDD:238106	106/186 (57%)
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	104/183 (57%)
		PHA03307	300..>467	CDD:223039	33/140 (24%)
		TBX	305..383	CDD:403708	24/110 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..450		25/114 (22%)
		Repression domain 1 (RD1)	518..601
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..687

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810