Protein Alignment Doc3 and TBX1

DIOPT Version :9

• Sequence 1: NP_648280.1
• Gene: Doc3 / 39036
• FlyBaseID: FBgn0035954
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: XP_016884414.1
• Gene: TBX1 / 6899
• HGNCID: 11592
• Length: 545
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 149/465 - (32%)
• Similarity: 201/465 - (43%)
• Gaps: 141/465 - (30%)

  Fly    31 DPLCGLLPNFAGHFMPPPPP----------------PQPTLPG------------------DVEA 61
            ||.....|...|   |||||                .:|..||                  .|..
Human   101 DPCAAAAPGAPG---PPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAKVAGVSV 162

  Fly    62 KLENNELWQQFHSIGTEMIITKCGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYK--FSGS 124
            :||...||.:|:.:|||||:||.||||||:.:|.|.|::..|.|.:|::.||:.|.||:  |..|
Human   163 QLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSS 227

  Fly   125 QWVPAGGAEPQSPQRMYLHPESPATGKHWQSQALLFSKVKLTNNTLDNNGHIVLASMHKYQPRLH 189
            .|:.||.|:|.:|.|::.||:|||.|..|..|.:.|.|:|||||.||:||||:|.|||:||||.|
Human   228 SWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFH 292

  Fly   190 VIRT---SDLGQIPWAPQQAFIFPETEFIAVTAYQNDRITKLKIDNNPFAKGFRESG-------- 243
            |:..   .|..:......:.|:|.||.|.|||||||.|||:|||.:||||||||:..
Human   293 VVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNH 357

  Fly   244 -------QSRCKRKINDSPPPTQPEANQVDRSPV------------------------------- 270
                   .|...|..|....||||...:.|.:..
Human   358 RPGALPLMSAFARSRNPVASPTQPSGTEKDAAEARREFQRDAGGPAVLGDPAHPPQLLARVLSPS 422

  Fly   271 --------------------TSPLAKRLRLVEEFP----QHHHHQSHHSVPMQRHYLLDALEANF 311
                                .||....|||  |.|    ..|||...:......|||  ..::.
Human   423 LPGAGGAGGLVPLPGAPGGRPSPPNPELRL--EAPGASEPLHHHPYKYPAAAYDHYL--GAKSR- 482

  Fly   312 YVPAP-PPPAIE---YARHIGGAYPSWAYTPPSPASSVSSSSAGSTSGESAADREADADADTFVD 372
              ||| |.|.:.   |..|   |:|...:.|.|||::.::::|.:.:.               .:
Human   483 --PAPYPLPGLRGHGYHPH---AHPHHHHHPVSPAAAAAAAAAAAAAA---------------AN 527

  Fly   373 VVGTAPAAPP 382
            :..:|.||||
Human   528 MYSSAGAAPP 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	TBOX	58..245	CDD:238106	97/206 (47%)
TBX1	XP_016884414.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910