DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doc3 and tbx1

DIOPT Version :9

Sequence 1:	NP_648280.1	Gene:	Doc3 / 39036	FlyBaseID:	FBgn0035954	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001030290.1	Gene:	tbx1 / 619587	XenbaseID:	XB-GENE-478084	Length:	463	Species:	Xenopus tropicalis

Alignment Length:	385	Identity:	136/385 - (35%)
Similarity:	183/385 - (47%)	Gaps:	71/385 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DVEAKLENNELWQQFHSIGTEMIITKCGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYK-- 120
            ::..:||...||.:|:.:|||||:||.||||||:.:|.:.|::..|.|.:|::.||:.|.||:
Frog   109 NITVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFVPVDDKRYRYA 173

  Fly   121 FSGSQWVPAGGAEPQSPQRMYLHPESPATGKHWQSQALLFSKVKLTNNTLDNNGHIVLASMHKYQ 185
            |..|.|:.||.|:|.:|.|::.||:|||.|..|..|.:.|.|:|||||.||:||||:|.|||:||
Frog   174 FHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQ 238

  Fly   186 PRLHVIRT---SDLGQIPWAPQQAFIFPETEFIAVTAYQNDRITKLKIDNNPFAKGFRESGQSRC 247
            ||.||:..   .|..:......:.|:|.||.|.|||||||.|||:|||.:||||||||:......
Frog   239 PRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDW 303

  Fly   248 KRKINDSPPPTQPEANQVDRS--PVTSPLAKRLRLVEEFPQH----------HHHQSHHSVPMQR 300
            .|   :..|.:.|..|...||  ||:||           ||:          .:.:.....|:..
Frog   304 PR---NHRPGSLPLMNAFARSRNPVSSP-----------PQNGSDKDGDGRREYERDTSGTPLHG 354

  Fly   301 HYLLDALEANFYVPAPPPPAIEYARHIGGAYPSWAYTPPSPAS-SVSSSSAGST-------SGES 357
            ......|.:....|:.|.|        ||..|.....|..|.. .:...|.||.       ...:
Frog   355 DAAHQQLMSRVLSPSLPVP--------GGLVPLSTGRPSPPHELRLDPHSQGSEPLHHHPYKYPT 411

  Fly   358 AADREADADADTFVDVVGTAPAAPPPPS---------PPVPATAT------APASSSSDP 402
            :.|....|.         |.||..|.||         |..||.|.      ||.|....|
Frog   412 SYDHYLGAK---------TRPAPYPLPSIRGHGYHHHPMNPAAANMYSGAGAPGSYEYGP 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	TBOX	58..245	CDD:238106	95/191 (50%)
tbx1	NP_001030290.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..103
		T-box	112..297	CDD:366363	94/184 (51%)
		T-box	114..297		94/182 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..354		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..405		11/45 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100