Protein Alignment Doc3 and Tbx5

DIOPT Version :10

• Sequence 1: NP_648280.1
• Gene: Doc3 / 39036
• FlyBaseID: FBgn0035954
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_001009964.1
• Gene: Tbx5 / 304514
• RGDID: 1305702
• Length: 517
• Species: Rattus norvegicus
• Alignment Length: 422
• Identity: 152/422 - (36%)
• Similarity: 206/422 - (48%)
• Gaps: 63/422 - (14%)

  Fly    31 DPLCGLLPNFA-GHFMPPPPPPQP--TLPG--DVEAKLENNELWQQFHSIGTEMIITKCGRRMFP 90
            |..|...|..| |.....|..||.  |..|  .::..|...|||.:||.:||||||||.||:|||
  Rat    21 DRSCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRQMFP 85

  Fly    91 SMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPESPATGKHWQS 155
            |.:|.::||..:..|.:|:::||..|.||||:.::|...|.|||..|.|:|:||:|||||.||..
  Rat    86 SYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMR 150

  Fly   156 QALLFSKVKLTNNTLDNNGHIVLASMHKYQPRLHVIRTSD---LGQIPWAPQQAF---IFPETEF 214
            |.:.|.|:|||||.||..|||:|.||||||||||:::..:   .|    :...||   :||||.|
  Rat   151 QLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFG----SKNTAFCTHVFPETAF 211

  Fly   215 IAVTAYQNDRITKLKIDNNPFAKGFRESG------QSRCKRKINDSPPPTQPEANQVDRSPVTSP 273
            ||||:|||.:||:|||:|||||||||.|.      .||.:.|.....|.:.......:.||.:|.
  Rat   212 IAVTSYQNHKITQLKIENNPFAKGFRGSDDLELHRMSRMRSKEYPVVPRSTVRHKVANHSPFSSE 276

  Fly   274 LAKRLRLVEEFPQHHHHQSHHSVPMQRHYLLDALEANFYVPAPPPPAIEYARHIGGAY------- 331
             .:.|.........:..::..|.|.|     |.|        |||.....|:.....|
  Rat   277 -TRALSTSSNLGSQYQCENGVSGPSQ-----DLL--------PPPNPYPLAQEHSQIYHCTKRKD 327

  Fly   332 -----------PSWAYTPPSPASSVSSSSAGSTSGESAADREADADADTFVDVVGTAPAAPPPPS 385
                       ..:..|.||...:...|......|.|.:.|...|.....:      .|:..|||
  Rat   328 EECSSTEHPYKKPYMETSPSEEDTFYRSGYPQQQGLSTSYRTESAQRQACM------YASSAPPS 386

  Fly   386 PPVPATATAPASSSSDPTMAKPKRSSFSISDI 417
            .|||  :....|.::.|:|  |..||.:::.:
  Rat   387 EPVP--SLEDISCNTWPSM--PSYSSCTVTTV 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	T-box_Drosocross-like	59..241	CDD:410332	101/187 (54%)
Tbx5	NP_001009964.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		8/24 (33%)
		T-box_TBX4_5-like	54..238	CDD:410315	101/187 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..313		12/56 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..369		6/37 (16%)