DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doc3 and Tbx5

DIOPT Version :9

Sequence 1:	NP_648280.1	Gene:	Doc3 / 39036	FlyBaseID:	FBgn0035954	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001009964.1	Gene:	Tbx5 / 304514	RGDID:	1305702	Length:	517	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	152/422 - (36%)
Similarity:	206/422 - (48%)	Gaps:	63/422 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DPLCGLLPNFA-GHFMPPPPPPQP--TLPG--DVEAKLENNELWQQFHSIGTEMIITKCGRRMFP 90
            |..|...|..| |.....|..||.  |..|  .::..|...|||.:||.:||||||||.||:|||
  Rat    21 DRSCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRQMFP 85

  Fly    91 SMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPESPATGKHWQS 155
            |.:|.::||..:..|.:|:::||..|.||||:.::|...|.|||..|.|:|:||:|||||.||..
  Rat    86 SYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMR 150

  Fly   156 QALLFSKVKLTNNTLDNNGHIVLASMHKYQPRLHVIRTSD---LGQIPWAPQQAF---IFPETEF 214
            |.:.|.|:|||||.||..|||:|.||||||||||:::..:   .|    :...||   :||||.|
  Rat   151 QLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFG----SKNTAFCTHVFPETAF 211

  Fly   215 IAVTAYQNDRITKLKIDNNPFAKGFRESG------QSRCKRKINDSPPPTQPEANQVDRSPVTSP 273
            ||||:|||.:||:|||:|||||||||.|.      .||.:.|.....|.:.......:.||.:|.
  Rat   212 IAVTSYQNHKITQLKIENNPFAKGFRGSDDLELHRMSRMRSKEYPVVPRSTVRHKVANHSPFSSE 276

  Fly   274 LAKRLRLVEEFPQHHHHQSHHSVPMQRHYLLDALEANFYVPAPPPPAIEYARHIGGAY------- 331
             .:.|.........:..::..|.|.|     |.|        |||.....|:.....|
  Rat   277 -TRALSTSSNLGSQYQCENGVSGPSQ-----DLL--------PPPNPYPLAQEHSQIYHCTKRKD 327

  Fly   332 -----------PSWAYTPPSPASSVSSSSAGSTSGESAADREADADADTFVDVVGTAPAAPPPPS 385
                       ..:..|.||...:...|......|.|.:.|...|.....:      .|:..|||
  Rat   328 EECSSTEHPYKKPYMETSPSEEDTFYRSGYPQQQGLSTSYRTESAQRQACM------YASSAPPS 386

  Fly   386 PPVPATATAPASSSSDPTMAKPKRSSFSISDI 417
            .|||  :....|.::.|:|  |..||.:::.:
  Rat   387 EPVP--SLEDISCNTWPSM--PSYSSCTVTTV 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	TBOX	58..245	CDD:238106	103/198 (52%)
Tbx5	NP_001009964.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		8/24 (33%)
		TBOX	53..241	CDD:238106	103/191 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..313		12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..369		6/37 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910