DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc3 and tbx2b

DIOPT Version :9

Sequence 1:	NP_648280.1	Gene:	Doc3 / 39036	FlyBaseID:	FBgn0035954	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_571126.1	Gene:	tbx2b / 30253	ZFINID:	ZDB-GENE-990726-27	Length:	687	Species:	Danio rerio

Alignment Length:	374	Identity:	140/374 - (37%)
Similarity:	205/374 - (54%)	Gaps:	57/374 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 PQPTLPGDVEAKLENNELWQQFHSIGTEMIITKCGRRMFPSMRVSLSGLEEEASYCVLLEMVPIG 115
            |:..:..|.:..||..:||.|||.:||||:|||.||||||..:|.::||:::|.|.:|:::|...
Zfish    86 PEEEVEDDPKVTLEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRINGLDKKAKYILLMDIVAAD 150

  Fly   116 DCRYKFSGSQWVPAGGAEPQSPQRMYLHPESPATGKHWQSQALLFSKVKLTNNTLDNNGHIVLAS 180
            ||||||..|:|:.||.|:|:.|:|||:||:|||||:.|.::.:.|.|:|||||..|.:|..:|.|
Zfish   151 DCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNS 215

  Fly   181 MHKYQPRLHVIRTSDLGQIPWAPQQAFIFPETEFIAVTAYQNDRITKLKIDNNPFAKGFRESGQS 245
            |||||||.|::|.:|:.::|::..:.::||||:||||||||||:||:|||||||||||||::|..
Zfish   216 MHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNG 280

  Fly   246 RCKRKINDSPPPTQPEANQVDRSPVTSPLAKRLRLVEEFPQHHHHQSHHSVPMQRHYLLDALEAN 310
            |.::                 |..:|.|   .||:.|:                 ...:|...|:
Zfish   281 RREK-----------------RKQLTLP---SLRMYED-----------------QCKVDRDGAD 308

  Fly   311 FYVPAPPPPAIEYARHIGGAYPSWAYTPPSPASSVSSSSAGSTSGESAADREADADADTFVDVVG 375
            ....:..|.....|.|           .|.|.||....:.||...::..|.|.:.|...  |..|
Zfish   309 SDASSSEPTTGRDAGH-----------SPGPVSSPLRFNRGSRDDKTCTDSEHEMDHQN--DRCG 360

  Fly   376 TAPAAPPPPSPPVPATA-----TAPASSSSD--PTMAKPKRSSFSISDI 417
            .:.:..|.||.|..:.:     ..|.:...|  |...|...|.|||.::
Zfish   361 GSSSPAPKPSSPFRSRSEDWGREKPIAEKKDDYPDSRKTSDSIFSIRNL 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	TBOX	58..245	CDD:238106	104/186 (56%)
tbx2b	NP_571126.1	TBOX	95..278	CDD:238106	102/182 (56%)
		TBX	294..361	CDD:204975	17/96 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..452		28/120 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810