DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doc3 and tbx6

DIOPT Version :9

Sequence 1:	NP_648280.1	Gene:	Doc3 / 39036	FlyBaseID:	FBgn0035954	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_705952.2	Gene:	tbx6 / 192294	ZFINID:	ZDB-GENE-020416-5	Length:	874	Species:	Danio rerio

Alignment Length:	446	Identity:	158/446 - (35%)
Similarity:	221/446 - (49%)	Gaps:	87/446 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QRLPD--------PLCGLLPNFAGHFMPP-----------PPPPQPTLPGDVEAKLENNELWQQF 72
            |||.|        ||.......|...:||           |..||.:    |..:|||..||:||
Zfish    15 QRLSDCYYRDRDVPLYPSTCEMAARALPPALLKPHANTDSPATPQDS----VRMELENAGLWKQF 75

  Fly    73 HSIGTEMIITKCGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSP 137
            .::|||||:||.||||||.:||.||||.....|.:||::||:...||:|..:.|...||||.:.|
Zfish    76 STVGTEMIVTKKGRRMFPQLRVKLSGLNPSLRYILLLDIVPVDSSRYRFQDNSWQVVGGAEARLP 140

  Fly   138 QRMYLHPESPATGKHWQSQALLFSKVKLTNNTLDNNGHIVLASMHKYQPRLHVIRTSDLGQIPWA 202
            .|:::||:|||||:|||::.:.|.:.||||||||..|:|:|.|:|:||||:|||...|:  :.|.
Zfish   141 DRVFIHPDSPATGEHWQNRTISFHRAKLTNNTLDAQGYIILHSLHRYQPRVHVIEARDV--LMWG 203

  Fly   203 -PQQAFIFPETEFIAVTAYQNDRITKLKIDNNPFAKGFRESG-------QSRCKRKINDSPPPTQ 259
             .|.:|.||||:||.||||||::||:|||::|||||||||:|       ::|.||||..|    |
Zfish   204 RTQHSFTFPETQFITVTAYQNNKITELKINSNPFAKGFRENGMNCKKQREARLKRKITSS----Q 264

  Fly   260 PEANQVDR-SPVTSPLAKRLRLVEEFPQHHHHQSHHSVPMQRHYL------LDALEANFYVPAPP 317
            .|...::. .|..|        .|..||        ||.:....|      |...::.|:.....
Zfish   265 EECLDIESCDPCDS--------TELLPQ--------SVDLPSSALTIMNTALPITDSGFHTEVSS 313

  Fly   318 PP---------AIEYARHIGGAYPSWAYTPPSPASSVSSSSAGSTSGESAADREADADADTFVDV 373
            .|         .:|.| .:....||            |..|...|:.|:..:.....:....:|:
Zfish   314 HPDQTDSDQTLVLEQA-FLTSEMPS------------SMESQQQTTSETNVNNALMDETGQMMDL 365

  Fly   374 VGTAPAAPPP-----PSPPVPATATAPASSSSDPTMAKPKRSSFSISDILGTSSSI 424
            .|...:.|.|     .|.|..::..:..||:....:..|:.||.|....:...|||
Zfish   366 SGYTSSFPTPQLSSHTSVPQSSSMYSVVSSTQSSDLELPQASSISSPHSMPAYSSI 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	TBOX	58..245	CDD:238106	104/194 (54%)
tbx6	NP_705952.2	TBOX	62..247	CDD:238106	104/186 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..453
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..551
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..626
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..695
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574472
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6331
SonicParanoid	1	1.000	-	-		X4271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.830