DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doc3 and eomes

DIOPT Version :9

Sequence 1:	NP_648280.1	Gene:	Doc3 / 39036	FlyBaseID:	FBgn0035954	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001122124.1	Gene:	eomes / 100038065	XenbaseID:	XB-GENE-479769	Length:	667	Species:	Xenopus tropicalis

Alignment Length:	451	Identity:	152/451 - (33%)
Similarity:	202/451 - (44%)	Gaps:	107/451 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PLCGLLPNFAGHF--------MPPPPPPQPT--------LPG---DVEAK--LENNELWQQFHSI 75
            |:|...|.::..:        |..|.||..|        |||   .|.|:  |.|..||.:||..
Frog   181 PVCPSRPQYSSGYQYSQAPGTMYSPYPPAGTGSGLSALGLPGGGAGVRAQVFLCNRPLWLKFHRH 245

  Fly    76 GTEMIITKCGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWVPAGGAE-PQSPQR 139
            .|||||||.||||||.:..:::||...|.|.|.:|:|......::|.|.:||..|.|: .....:
Frog   246 QTEMIITKQGRRMFPFLSFNITGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNK 310

  Fly   140 MYLHPESPATGKHWQSQALLFSKVKLTNNTLDNNGH---IVLASMHKYQPRLHVIRTS-----DL 196
            :|:|||||.||.||..|.:.|.|:|||||...||..   |||.|:||||||||::..|     ||
Frog   311 VYVHPESPNTGAHWMRQEISFGKLKLTNNKGANNNSTQMIVLQSLHKYQPRLHIVEVSEDGVEDL 375

  Fly   197 GQIPWAPQQAFIFPETEFIAVTAYQNDRITKLKIDNNPFAKGFRESGQSRCKRKINDSPPPTQPE 261
            ...  |..|.|.||||:|||||||||..||:||||:||||||||::..|..          |..|
Frog   376 NDS--AKSQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMY----------TASE 428

  Fly   262 ANQVDRSPVTSPLAKRL--------------RLVEEFPQHHHHQSHHSVPMQRHYLLDALEANFY 312
            ::::..||..||.:.::              :.|...|...::....:|| |.:.||.....:..
Frog   429 SDRLTPSPADSPRSHQIVPGTRYSVQPFFQDQFVNNLPPARYYSGERTVP-QANGLLSPQTNDEV 492

  Fly   313 VPAPPPPAIEYARHIGGAYPSWAYTPPSPASS--------VSSSSAGS------------TSGES 357
            ..|||              ..|..||...|::        .:..|:||            ||...
Frog   493 ANAPP--------------QRWFVTPVQQAAANKLDMGAYETDYSSGSLLTYGIKSLPIQTSHPM 543

  Fly   358 AADREADADADTFVDVVGTAPAAPPPPSPPVPATATAPASSSSDPTMAKPKRSSFSISDIL 418
            |...:|     .|..:.|.....   .:.....|.|.|.||.|.|       |.|| .|:|
Frog   544 AYYPDA-----AFASMAGWGSRG---STYQRKMTTTLPWSSRSSP-------SGFS-EDLL 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doc3	NP_648280.1	TBOX	58..245	CDD:238106	99/197 (50%)
eomes	NP_001122124.1	T-box	231..418	CDD:366363	96/188 (51%)
eomes	NP_001122124.1	T-box_assoc	444..665	CDD:374412	35/176 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100