DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and AREL1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001034568.1	Gene:	AREL1 / 9870	HGNCID:	20363	Length:	823	Species:	Homo sapiens

Alignment Length:	748	Identity:	171/748 - (22%)
Similarity:	289/748 - (38%)	Gaps:	208/748 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 RIEFQSPQQPSISNLLRRALERSSTRGVNLMG--------------VASSKQSKQQWRKLDSAEV 467
            |.|:.:|...|:|  ||.  |.:.|..::.:|              |.|::|:.|.:.:|
Human   192 RDEYDNPTNNSMS--LRD--EHNYTLSIHELGPQEEESTGVSFEKSVTSNRQTFQVFLRL----- 247

  Fly   468 VQVSRICGMYYAALNTLSQM----KLDIL----------------TGI-CYSDNVLYDIWLLITS 511
            ...||  |.::|.::..:|.    :.||:                :|: .|.:..||:
Human   248 TLHSR--GCFHACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAYLYN------- 303

  Fly   512 LGPNCGMKE-YLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEH------EMYTEQ---NPFK 566
             ..||.... :|..:...::.::|.||               :||.      |.:|.:   .|.|
Human   304 -ATNCSSTPWHLPPMHMTSSQRRPSTA---------------VDEEDEDSPSECHTPEKVKKPKK 352

  Fly   567 LNDYV------LLTYFLNNILYKLINDNLLAGAK------------------NIVQHPVFLSLHT 607
            :..||      :..::|..|.::|....:..|.|                  :.:|.||.||
Human   353 VYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELS--- 414

  Fly   608 LMLCLYRRDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFV 672
               |..|                .:..:|||..|.|....:...          :|:|..|::
Human   415 ---CKER----------------NILAATFIRSLHKNIGGSETF----------QDKVNFFQR-- 448

  Fly   673 QNEKAVMGLTESACASPRSAL-IVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGI 736
                   .|.:.....|.|.: :.:.|..::|...:...............|.|.:::.|
Human   449 -------ELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEAL----- 501

  Fly   737 DQDGVFKEFLEETIKKVFDPSLNLFKTTSDQR---LYPSPISYVQDNHLEL--FEFVGRMLGKAV 796
            |..|..:|:.|...|.:||.:..||...||..   ::|:|   .:..||.|  :||.||::||.:
Human   502 DWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNP---NRPAHLRLKMYEFAGRLVGKCL 563

  Fly   797 YEGI-------VVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRS-LTFIKHYKQDVSDL 853
            ||..       :|...|...||:|::|......|...|     |.|.|:| :.||  ...|:|::
Human   564 YESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETD-----DPEFYKSKVCFI--LNNDMSEM 621

  Fly   854 NLTFSVDQ----DVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFR 914
            .|.|:.::    ..:.|:|.|.  .||....|.:.||:.|::.:|.:.:.:|::|:...|.:|..
Human   622 ELVFAEEKYNKSGQLDKVVELM--TGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLN 684

  Fly   915 SIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGG-FHDTHQVVCWLWDILAKDFTEEE 978
            .:|....|::|...||:.|:.| |..:.:.|.:.|....|| :|...:|:.|.|.::: ..|:||
Human   685 ELVPENLLAIFDENELELLMCG-TGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVS-SLTQEE 747

  Fly   979 RKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTS 1043
            ....|:|.|..|:.|..|||.|.|.|.|......                         :.|||:
Human   748 LARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTH-------------------------STLPTA 787

  Fly  1044 STCFNLLKLPNYQKKSTLRDKLRYAVSSN-TGF 1075
            .||||.|.||.|.....:...|:.|:|.. .||
Human   788 HTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	108/401 (27%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	104/375 (28%)
AREL1	NP_001034568.1	Filamin	52..158
		Filamin	56..154	CDD:395505
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345		7/44 (16%)
		Interaction with SOCS2. /evidence=ECO:0000269\|PubMed:31578312	483..789		93/349 (27%)
		HECTc	486..820	CDD:214523	104/377 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810