Protein Alignment CG5087 and MAGI2

DIOPT Version :9

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: XP_016868329.1
• Gene: MAGI2 / 9863
• HGNCID: 18957
• Length: 1540
• Species: Homo sapiens
• Alignment Length: 878
• Identity: 158/878 - (17%)
• Similarity: 272/878 - (30%)
• Gaps: 345/878 - (39%)

  Fly   149 LPELKP-----ENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQPAMQKIC-------CNI 201
            |.|:||     |:.:..:|..|.|.   |...|.:...:|:..      |:.|.|       |..
Human    44 LGEVKPGKVAYESGSKLVSEELLLE---VNETPVAGLTIRDVL------AVIKHCKDPLRLKCVK 99

  Fly   202 QGHLVQHDFYKIMRLVLIRGTVREELS--VKPVTLVAIITLCLRPLIDGNFSRNLLAKFLSEILS 264
            ||.:|..|....:.|...:|:|..||.  ::....:..:....||..:|               .
Human   100 QGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEG---------------E 149

  Fly   265 VPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEE--FGTSMPGTKSLAFLGNIVNLFNI 327
            ||.:.| :..:|...:|...|..||:     ||.   :|:  :||..|..:....|.|:.:
Human   150 VPGVDY-IFITVEDFMELEKSGALLE-----SGT---YEDNYYGTPKPPAEPAPLLLNVTD---- 201

  Fly   328 DGQGESKELAYPLLTETTTSLLELIPNTVTTKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFH 392
                                  :::|..                 ||..|..:.:|
Human   202 ----------------------QILPGA-----------------TPSAEGKRKRN--------- 218

  Fly   393 MLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQ 457
                            |.:: |.|:...:.|::           |......||..||..:.:|.:
Human   219 ----------------KSVS-NMEKASIEPPEE-----------EEEERPVVNGNGVVVTPESSE 255

  Fly   458 QWRKLDSAEVVQVSR-ICGMYYAALNTLSQMKLDILTGICYSDN----VLYDIWLLITSLGPNCG 517
            ...|...|.....|: .....|:....|.: ::|........||    .|.|.|.:
Human   256 HEDKSAGASGEMPSQPYPAPVYSQPEELKE-QMDDTKPTKPEDNEEPDPLPDNWEM--------- 310

  Fly   518 MKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILD---------EHEMYTEQNPF---KLNDY 570
              .|.|  |.|           :.|.|..|...:.||         ..|....:.|:   |::|.
Human   311 --AYTE--KGE-----------VYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP 360

  Fly   571 VLLTYFLNNILYKLINDN-LLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPP------KHWL 628
            :..||::::|..:...:| :|...:.:.||.:   .||.:       ..:|...|      ..|.
Human   361 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNM---PHTEL-------GTKPLQAPGFRVDSSSWT 415

  Fly   629 IP---EVKP------STFINDL--------------EKA--KRNAMLL----------------- 651
            :|   .::|      |..:|||              ||.  .|:|..|
Human   416 LPRPKSIRPRAAPERSRSVNDLSYYQRDPAGRPWLFEKPLFTRDASQLKGTFLSTTLKKSNMGFG 480

  Fly   652 -----------LAKMPHIIP----------------------------HEDRVKLFRKFVQNEKA 677
                       ..::..:||                            |.|.||||      :..
Human   481 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLF------QSV 539

  Fly   678 VMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQ-------GLHEAG 735
            .:|         :|..:|:.|      || .|...|......::....|.::       |.|..
Human   540 PIG---------QSVNLVLCR------GY-PLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNY- 587

  Fly   736 IDQDGVFKEFLEETIKKVFD----PSLNLFKTTSDQRL---YPSPISYVQDNHLELFE---FVGR 790
                ..:.|::..|.:.|.|    |..:|....:|.:|   ||.|   |.|:::.:..   ....
Human   588 ----ETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPP---VHDDNVSMASSGATQAE 645

  Fly   791 MLGKAVYEG------IVVDVPFASFFLSQLLGQTQQALYSCMD--ELPSL-DNELYRSLTFIKHY 846
            ::...:.:|      .:.|.|            |.|.:...:|  ..|.| :.:|     .::..
Human   646 LMTLTIVKGAQGFGFTIADSP------------TGQRVKQILDIQGCPGLCEGDL-----IVEIN 693

  Fly   847 KQDVSDLNLTFSVD--QDV-MGKIVTLALHPGG 876
            :|:|.:|:.|..||  :|. :|...:|.:|.||
Human   694 QQNVQNLSHTEVVDILKDCPIGSETSLIIHRGG 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	43/212 (20%)
		HECTc	718..1075	CDD:214523	37/188 (20%)
MAGI2	XP_016868329.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900