DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and Hecw1

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	XP_006516872.1	Gene:	Hecw1 / 94253	MGIID:	2444115	Length:	1605	Species:	Mus musculus

Alignment Length:	1005	Identity:	233/1005 - (23%)
Similarity:	369/1005 - (36%)	Gaps:	282/1005 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 LTLLPELKPENH----------------ADSLSLALFLHTLVVFT-------APKSWAILRNA-- 185
            ::.||.|:||:|                .||.....::..:...|       ||....::|:.
Mouse   809 ISQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHINRTTTWQRPSMAPTPDGMIRSGSV 873

  Fly   186 -QFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRG-------------------TVREELSVK 230
             |.|:|....|.|...:.....:.|........:..|                   .:|.|.|:.
Mouse   874 HQMEQLNRRYQNIQRTMATERAEEDSGNQNSEQIPDGGGGGGGGSDSEAESSQSSLDLRREGSLS 938

  Fly   231 PVTLVAIITLCLRPLIDGNFSRNLLAKFLS--EILSVPALIYHLQQSVPQCLEQFSSMGLLK-KA 292
            ||....:..|...|.:          ||::  |..:|    .|...|   ....|:|...|| ..
Mouse   939 PVNSQKVTLLLQSPAV----------KFITNPEFFTV----LHANYS---AYRVFTSSTCLKHMI 986

  Fly   293 LSISGDVQWFEEFGTSMPGTKSLAFLGNIVNLFNIDGQGESKELAYPLLTETTTSLLELIPNTVT 357
            |.:..|.:.||.:..:..       |.|.:|:|                   ..:.||| |.
Mouse   987 LKVRRDARNFERYQHNRD-------LVNFINMF-------------------ADTRLEL-PR--- 1021

  Fly   358 TKGVFTQWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQS 422
                        ||..    ...:|.     |.|.:  ||                |.....|..
Mouse  1022 ------------GWEI----KTDHQG-----KSFFV--DH----------------NSRATTFID 1047

  Fly   423 PQQPSISNLLRRALERSSTRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICG---------MYY 478
            |:.|..:..|...|              :.:|..|:.|...:.|..:|||..|         ...
Mouse  1048 PRIPLQNGRLPNHL--------------THRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLI 1098

  Fly   479 AALNTLSQMKLDILTGICYSDNVLY-----DIWLLI----TSLGPNCGMKEYLELLKSETN--LQ 532
            ||:.  ||.:.:.|. :.|:|.::.     :|:.::    .||..|..::|.:..:::|.|  |.
Mouse  1099 AAIR--SQHQHESLP-LAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLD 1160

  Fly   533 KPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLAGAKNIV 597
            |       |.||.                       |.|        ||..|..:.:::..
Mouse  1161 K-------LSCDA-----------------------DLV--------ILLSLFEEEIMSYV---- 1183

  Fly   598 QHPVFLSLHTLMLCLYR-RDCRRPFTPPKHWLIPEVKPSTFINDLEKAKRNAMLLLAKMPHIIPH 661
              |:..:.|.......| ..|..|...|.........||.:..|.|...||
Mouse  1184 --PLQSAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRN-------------- 1232

  Fly   662 EDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQAL-KGVIRVRF 725
                 .:||.   |....|      ..|....::|.||.::|..:.|:.|...:.| :..:.:.|
Mouse  1233 -----FYRKL---EAKGFG------QGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITF 1283

  Fly   726 INQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTTSDQ--RLYPSPISYVQDNHLELFEFV 788
            :.::||     |..|..:||.....:::|:|...||:.:::.  .:..||:|...:|:||.|.|.
Mouse  1284 VGEEGL-----DYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENYLEWFRFS 1343

  Fly   789 GRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSD- 852
            ||:||.|:....::|..|...|...||     .|...:.:|..||.|.::||.::|  ..:::|
Mouse  1344 GRILGLALIHQYLLDAFFTRPFYKGLL-----KLPCDLSDLEYLDEEFHQSLQWMK--DNNITDI 1401

  Fly   853 LNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIV 917
            |:|||:|:::|.|::....|..||....|.:.||..||..|..:.:...:.:||.|..|||..:|
Mouse  1402 LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALLRGFYEVV 1466

  Fly   918 NPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLF 982
            :...:|:|...||:.:|:| |:.:||.|.:.:|.|.||:||.|.|:.|.|..:.: |..|:|...
Mouse  1467 DSRLVSVFDARELELVIAG-TAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVER-FNNEQRLRL 1529

  Fly   983 LKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCF 1047
            |:|||..|..|..|||.|.....:|                    .|.|.|...:..||.:.|||
Mouse  1530 LQFVTGTSSVPYEGFAALRGSNGLR--------------------RFCIEKWGKITSLPRAHTCF 1574

  Fly  1048 NLLKLPNYQKKSTLRDKLRYAVSSNTGFEL 1077
            |.|.||.|...|.|.:||..||...:.|.|
Mouse  1575 NRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	121/385 (31%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	114/359 (32%)
Hecw1	XP_006516872.1	HECW_N	66..185	CDD:374632
		C2_NEDL1-like	206..342	CDD:176073
		Neuromodulin	378..500	CDD:369001
		WW	829..858	CDD:366073	3/28 (11%)
		HECW1_helix	947..1013	CDD:375862	20/108 (19%)
		WW	1019..1050	CDD:197736	12/73 (16%)
		HECTc	1249..1603	CDD:238033	121/387 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810