Protein Alignment CG5087 and UBE3B

DIOPT Version :10

• Sequence 1: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_569733.2
• Gene: UBE3B / 89910
• HGNCID: 13478
• Length: 1068
• Species: Homo sapiens
• Alignment Length: 1095
• Identity: 529/1095 - (48%)
• Similarity: 717/1095 - (65%)
• Gaps: 44/1095 - (4%)

  Fly     1 MF--AQNQKASFLEQTKAAREERALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENH 63
            ||  :|..:|.|:::.:.|||||.::|.||:||:::|:.::.:..|.:.|:.|..:.|..|  ..
Human     1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFF--KA 63

  Fly    64 DDKDAELELVASNVYPVLRRYLTQIRLDKSDVRARERLERICRYIIKAMESEN-TKLSYAALCLF 127
            ||.:: .:..|..::.:.|:.|...|: |.|   .||.|::||.|:.:|::|| .|:.|.:|...
Human    64 DDPES-TKRSALCIFKIARKLLFLFRI-KED---NERFEKLCRSILSSMDAENEPKVWYVSLACS 123

  Fly   128 KERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQP 192
            |:.:|.||..||.:|..|...|.:||||...||..:.|:|..||.||...:|.||| .:.|.|:|
Human   124 KDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILR-GKGESLRP 187

  Fly   193 AMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAK 257
            ||..||.||.|||.||.||.:::::|.||..|....:...||.|..:|.|||:|...||.||:..
Human   188 AMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRP 252

  Fly   258 FLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEEFGTSMPGTKSLAFLGNIV 322
            ||..|:|||||:.||....|:.|....|..:|:|.:....|.....:...|:.|..:|..:||::
Human   253 FLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDVCESLEGCHTLCLMGNLL 317

  Fly   323 NLFNIDGQGESKELAYPLLTETTTSLLELIPNTV--------TTKGVFTQWHELLGWHTPGPEPA 379
            :|.::..:         :|.|.|...:.|:..|:        ..|...|.||.:|||.:...:..
Human   318 HLGSLSPR---------VLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYG 373

  Fly   380 QNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPS----ISNLLRRALERS- 439
            .|:::.||.||...||....|::...|:|.:..|..:......|..|.    :.:||:||.::|
Human   374 LNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASPQNVLPVKSLLKRAFQKSA 438

  Fly   440 STRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYD 504
            |.|  |::.....|       ::|||||.:|..||.:|..:|.||:|::|.||||:.|.|::|..
Human   439 SVR--NILRPVGGK-------RVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPK 494

  Fly   505 IWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLND 569
            :|..|..|||:.|:|.:||.|.::|...|...|||||||||..|.:||||:.|:|.||..|||.:
Human   495 LWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEE 559

  Fly   570 YVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKP 634
            .|.::.|||:.::|:|.|.::..||..... :|.|:|..::.||.|||||.|||..|||..::||
Human   560 LVTISSFLNSFVFKMIWDGIVENAKGETLE-LFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKP 623

  Fly   635 STFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRD 699
            |....:|::.::.|.|:|..:||:|||::||.|||..|..||..:||.|::.|||....|.|.|.
Human   624 SVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRS 688

  Fly   700 RIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTT 764
            |::||||.||......|:||||||:|:|..|:.||||||||||||||||.||:||||:|||||||
Human   689 RMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTT 753

  Fly   765 S-DQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDE 828
            | |:||||||.||:.:|:|:||||||:||||||||||||||||||||||||||......||.:||
Human   754 SGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDE 818

  Fly   829 LPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYM 893
            |||||:|.|::||.||.|..|::||.||.|.|:||||::|...|.||||...|.:.||:.|||.|
Human   819 LPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLM 883

  Fly   894 AFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHD 958
            |.|.|:|||:.||.|...|||||:.|||:.:||.||||||||||.:.:||:||:|||.||||||.
Human   884 AHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHG 948

  Fly   959 THQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGS 1023
            :|:|:.|||||||.|||.:||.:|||||||||:|||||||:|:|||||||||||||:|||||:||
Human   949 SHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGS 1013

  Fly  1024 VIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
            |:||||.|||::|..|||||||||||||||||.|||.||:|||||:|.|||||||
Human  1014 VLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	IQCD	20..50	CDD:467745	10/29 (34%)
		HECTc	694..1076	CDD:238033	266/382 (70%)
UBE3B	NP_569733.2	HECTc	682..1066	CDD:238033	266/383 (69%)