DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and UBE3B

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_569733.2	Gene:	UBE3B / 89910	HGNCID:	13478	Length:	1068	Species:	Homo sapiens

Alignment Length:	1095	Identity:	529/1095 - (48%)
Similarity:	717/1095 - (65%)	Gaps:	44/1095 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MF--AQNQKASFLEQTKAAREERALEKRREQAAILLQSTLKGYAARRKYQKRIILDFDAMFTENH 63
            ||  :|..:|.|:::.:.|||||.::|.||:||:::|:.::.:..|.:.|:.|..:.|..|  ..
Human     1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFF--KA 63

  Fly    64 DDKDAELELVASNVYPVLRRYLTQIRLDKSDVRARERLERICRYIIKAMESEN-TKLSYAALCLF 127
            ||.:: .:..|..::.:.|:.|...|: |.|   .||.|::||.|:.:|::|| .|:.|.:|...
Human    64 DDPES-TKRSALCIFKIARKLLFLFRI-KED---NERFEKLCRSILSSMDAENEPKVWYVSLACS 123

  Fly   128 KERSLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQP 192
            |:.:|.||..||.:|..|...|.:||||...||..:.|:|..||.||...:|.||| .:.|.|:|
Human   124 KDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILR-GKGESLRP 187

  Fly   193 AMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLLAK 257
            ||..||.||.|||.||.||.:::::|.||..|....:...||.|..:|.|||:|...||.||:..
Human   188 AMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRP 252

  Fly   258 FLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSISGDVQWFEEFGTSMPGTKSLAFLGNIV 322
            ||..|:|||||:.||....|:.|....|..:|:|.:....|.....:...|:.|..:|..:||::
Human   253 FLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDVCESLEGCHTLCLMGNLL 317

  Fly   323 NLFNIDGQGESKELAYPLLTETTTSLLELIPNTV--------TTKGVFTQWHELLGWHTPGPEPA 379
            :|.::..:         :|.|.|...:.|:..|:        ..|...|.||.:|||.:...:..
Human   318 HLGSLSPR---------VLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYG 373

  Fly   380 QNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSPQQPS----ISNLLRRALERS- 439
            .|:::.||.||...||....|::...|:|.:..|..:......|..|.    :.:||:||.::|
Human   374 LNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASPQNVLPVKSLLKRAFQKSA 438

  Fly   440 STRGVNLMGVASSKQSKQQWRKLDSAEVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYD 504
            |.|  |::.....|       ::|||||.:|..||.:|..:|.||:|::|.||||:.|.|::|..
Human   439 SVR--NILRPVGGK-------RVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPK 494

  Fly   505 IWLLITSLGPNCGMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLND 569
            :|..|..|||:.|:|.:||.|.::|...|...|||||||||..|.:||||:.|:|.||..|||.:
Human   495 LWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEE 559

  Fly   570 YVLLTYFLNNILYKLINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTPPKHWLIPEVKP 634
            .|.::.|||:.::|:|.|.::..||..... :|.|:|..::.||.|||||.|||..|||..::||
Human   560 LVTISSFLNSFVFKMIWDGIVENAKGETLE-LFQSVHGWLMVLYERDCRRRFTPEDHWLRKDLKP 623

  Fly   635 STFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVIHRD 699
            |....:|::.::.|.|:|..:||:|||::||.|||..|..||..:||.|::.|||....|.|.|.
Human   624 SVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRS 688

  Fly   700 RIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLFKTT 764
            |::||||.||......|:||||||:|:|..|:.||||||||||||||||.||:||||:|||||||
Human   689 RMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTT 753

  Fly   765 S-DQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCMDE 828
            | |:||||||.||:.:|:|:||||||:||||||||||||||||||||||||||......||.:||
Human   754 SGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDE 818

  Fly   829 LPSLDNELYRSLTFIKHYKQDVSDLNLTFSVDQDVMGKIVTLALHPGGKARVVNDHNKLVYIHYM 893
            |||||:|.|::||.||.|..|::||.||.|.|:||||::|...|.||||...|.:.||:.|||.|
Human   819 LPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLM 883

  Fly   894 AFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQKHTHYYGGFHD 958
            |.|.|:|||:.||.|...|||||:.|||:.:||.||||||||||.:.:||:||:|||.||||||.
Human   884 AHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHG 948

  Fly   959 THQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGS 1023
            :|:|:.|||||||.|||.:||.:|||||||||:|||||||:|:|||||||||||||:|||||:||
Human   949 SHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGS 1013

  Fly  1024 VIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVSSNTGFELS 1078
            |:||||.|||::|..|||||||||||||||||.|||.||:|||||:|.|||||||
Human  1014 VLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	266/382 (70%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	254/357 (71%)
UBE3B	NP_569733.2	HECTc	682..1066	CDD:238033	266/383 (69%)
UBE3B	NP_569733.2	HECTc	707..1065	CDD:214523	254/357 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150748
Domainoid	1	1.000	505	1.000	Domainoid score	I330
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13775
Inparanoid	1	1.050	991	1.000	Inparanoid score	I307
Isobase	1	0.950	-	0	Normalized mean entropy	S2001
OMA	1	1.010	-	-		QHG48068
OrthoDB	1	1.010	-	-		D1163565at2759
OrthoFinder	1	1.000	-	-		FOG0006345
OrthoInspector	1	1.000	-	-		oto88459
orthoMCL	1	0.900	-	-		OOG6_100865
Panther	1	1.100	-	-	LDO	PTHR45700
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1831
SonicParanoid	1	1.000	-	-		X4619
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750