DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and HERC3

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_055421.1	Gene:	HERC3 / 8916	HGNCID:	4876	Length:	1050	Species:	Homo sapiens

Alignment Length:	983	Identity:	227/983 - (23%)
Similarity:	378/983 - (38%)	Gaps:	226/983 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 CLRPLIDGNF---SRN------LLAKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSIS 296
            ||....||.|   .:|      |..:|.|:  :.|..:..| :.:|  |.|.::.|....|||:|
Human   149 CLALAADGQFFTWGKNSHGQLGLGKEFPSQ--ASPQRVRSL-EGIP--LAQVAAGGAHSFALSLS 208

  Fly   297 GDVQWFEEFGTSMP--------------------------------GTKSLAFLGNIVNLFNIDG 329
            |.|     ||..|.                                |.:..|.|.....:|.. |
Human   209 GAV-----FGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTF-G 267

  Fly   330 QGESKELAYPLLTETTT--SLLELIPNTVTTKGVFTQWHEL-------------------LG-WH 372
            .|...:|.:..:.:...  .:|||:.:.||......| |.|                   || .|
Human   268 AGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQ-HTLAFVPSSGLIYAFGCGARGQLGTGH 331

  Fly   373 T-----PGPE----PAQNQNVALIKKQFHMLWDHRCIKLLL--GDLLKQINLNYER----IEFQS 422
            |     |.|.    .|.:..::....:|    .:..:|.:.  ||....:...||.    ::|::
Human   332 TCNVKCPSPVKGYWAAHSGQLSARADRF----KYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRT 392

  Fly   423 PQQPSISNLL---------RRALERSSTRGVNLMGVASSKQSKQQW------RKLD-----SAEV 467
            ..|...::|:         ::..|.::...:|  ||.....|...|      :|:|     |.::
Human   393 MNQAHYTSLINDETIAVWRQKLSEHNNANTIN--GVVQILSSAACWNGSFLEKKIDEHFKTSPKI 455

  Fly   468 --VQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLL--ITSLGPNC-GMKEYLELLKS 527
              :.::....::...:|:...|   ||..|..|    ::..|:  ::|..|:. .|:.||.|
Human   456 PGIDLNSTRVLFEKLMNSQHSM---ILEQILNS----FESCLIPQLSSSPPDVEAMRIYLIL--- 510

  Fly   528 ETNLQKPQTAMLMLFCDCMTHYVTI---LDEHEMYTEQNPFKLND----YVLLTYFLNNI-LYKL 584
                  |:..:|    ....:|:|:   |....:..:.||.|:.|    .|...||:..: |||.
Human   511 ------PEFPLL----QDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKG 565

  Fly   585 INDNLLAGAKNIVQHPVFLSLHT----LMLCLYRRDCRRPFTPPKHWLIPEVKPSTFIND----- 640
            ....||.|.|..:...:|.:..|    |:..||:.:.:........:.|||:.....|.:
Human   566 AVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMW 630

  Fly   641 -LEKAKRNA-------MLLLAKMPHIIPHEDRVKLFR--KFVQNEKAVMG---------LT-ESA 685
             |.:|...|       .:.|...|.|...:.:.|:.:  ..:|.:.||.|         || |..
Human   631 FLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPL 695

  Fly   686 CASPRSALIVIH--RDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEE 748
            .|  ||..:|:|  |:.:|.|..|:|:......||..::|.|..     |..:|..||.|||...
Human   696 LA--RSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDG-----EEAVDAGGVTKEFFLL 753

  Fly   749 TIKKVFDPSLNLFKTTSDQR-LYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLS 812
            .:|::.:|...:|....|.. |:.|...:|:.|   .|..:|...|.|:|...|||:.|......
Human   754 LLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHN---WFHLIGITCGLAIYNSTVVDLHFPLALYK 815

  Fly   813 QLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYK-QDVSD-LNLTFSVDQDVMGKIVTLALHPG 875
            :||.     :...:::|..|.....|||..:..|. :||.: ..|.|::.::..|.|....|.||
Human   816 KLLN-----VKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPG 875

  Fly   876 GKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSP 940
            |....|...|:..::.....:.....:.|...||:.||..:...:.|.||.|.||:.::.|: |.
Human   876 GDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN-SN 939

  Fly   941 LDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHLEPPFS 1005
            .:.::|::...|.|.:..||..|...|:.. .:|..|::|.||.|:|...:.|:.|.|.|:
Human   940 YNWEELEETAIYKGDYSATHPTVKLFWETF-HEFPLEKKKKFLLFLTGSDRIPIYGMASLQ---- 999

  Fly  1006 IRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRYAVS 1070
                .|.....:|:                  ..||.:.||:|||.||.|..|..|..:|..|:.
Human  1000 ----IVIQSTASGE------------------EYLPVAHTCYNLLDLPKYSSKEILSARLTQALD 1042

  Fly  1071 SNTGFELS 1078
            :..||.|:
Human  1043 NYEGFSLA 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	103/386 (27%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	94/359 (26%)
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	2..331	CDD:227511	41/193 (21%)
		RCC1 2	52..101
		RCC1 3	102..154		2/4 (50%)
		RCC1 4	156..207		14/55 (25%)
		RCC1 5	208..259		9/55 (16%)
		RCC1 6	261..311		12/51 (24%)
		RCC1	313..377	CDD:366085	11/67 (16%)
		RCC1 7	313..366		8/56 (14%)
		HECTc	702..1048	CDD:238033	103/386 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810