DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5087 and UFD4

DIOPT Version :9

Sequence 1:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_012915.3	Gene:	UFD4 / 853859	SGDID:	S000001493	Length:	1483	Species:	Saccharomyces cerevisiae

Alignment Length:	1460	Identity:	272/1460 - (18%)
Similarity:	485/1460 - (33%)	Gaps:	533/1460 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 REERALEK--RREQAAILLQSTLKGYAARRKY---------QKRIILDFDAMFTENHDDKDAELE 71
            |.||:.|.  |.|:.:.|:::|  |.|:...|         .:.|:     |..:...|:...:|
Yeast   158 RMERSAESSARNERISKLIENT--GNASEDPYIAMESLKELSENIL-----MMNQMVVDRIIPME 215

  Fly    72 LVASNVYPVLRRYLTQIRLDKSDVRARERLE---RICR-------------------YIIKAMES 114
            .:..|:..:|           ||...||.||   :.||                   ::|..::.
Yeast   216 TLIGNIAAIL-----------SDKILREELELQMQACRCMYNLFEVCPESISIAVDEHVIPILQG 269

  Fly   115 ENTKLSYAALCLFKERSLPWIAHIK------ILLTNCLTLLPELKPENHADSLSLALFLHTLVVF 173
            :..::||..|.   |:.|..:.:|.      ||.|..|::..:              |...|.:.
Yeast   270 KLVEISYIDLA---EQVLETVEYISRVHGRDILKTGQLSIYVQ--------------FFDFLTIH 317

  Fly   174 TAPKSWAILRNAQFEKLQPAMQKICCNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPV----TL 234
            ...|:.||:.||            |.:|:    ..||..|:.::         .::||:    |.
Yeast   318 AQRKAIAIVSNA------------CSSIR----TDDFKTIVEVL---------PTLKPIFSNATD 357

  Fly   235 VAIITLCLRPL------------IDGNFSRNLLAKFLSEILSVPALIYHLQQSVP-----QCLEQ 282
            ..|:|..:..:            .:..||.:|:.:.: :::|:        |..|     :||:.
Yeast   358 QPILTRLVNAMYGICGALHGVDKFETLFSLDLIERIV-QLVSI--------QDTPLENKLKCLDI 413

  Fly   283 FS----SMGLLKKALSISGDV-----QWFEEFGTS-----------MPGTKSLAFLGNIVNLFNI 327
            .:    |..:|.:.|....|:     :.|:.:..|           :|.:..::....||.||..
Yeast   414 LTVLAMSSDVLSRELREKTDIVDMATRSFQHYSKSPNAGLHETLIYVPNSLLISISRFIVVLFPP 478

  Fly   328 DGQ---------GESK--------------ELAYPLLTETTT-------------SLLELIP--N 354
            :.:         |.|.              :...|:|.|..|             :||.::.  |
Yeast   479 EDERILSADKYTGNSDRGVISNQEKFDSLVQCLIPILVEIYTNAADFDVRRYVLIALLRVVSCIN 543

  Fly   355 TVTTKGVFTQWHELLGWHTPGPEPAQNQN-----------------VALIKKQFHMLWDHRCIKL 402
            ..|.|.:..|..:|:|......|.|.|.|                 :.||.|:|..|:.....:.
Yeast   544 NSTAKAINDQLIKLIGSILAQKETASNANGTYSSEAGTLLVGGLSLLDLICKKFSELFFPSIKRE 608

  Fly   403 LLGDLLKQINLNYERIEFQ-------------------------------------------SPQ 424
            .:.||:|.:::::..|:.:                                           .|:
Yeast   609 GIFDLVKDLSVDFNNIDLKEDGNENISLSDEEGDLHSSIEECDEGDEEYDYEFTDMEIPDSVKPK 673

  Fly   425 QPSISNLLRRALERSSTRGVNLM----------------------GVAS-------SKQSKQQWR 460
            :.||......:|.....:||||:                      ||.|       ..::::.|:
Yeast   674 KISIHIFRTLSLAYIKNKGVNLVNRVLSQMNVEQEAITEELHQIEGVVSILENPSTPDKTEEDWK 738

  Fly   461 KLDSA-------EVVQVSRICGMYYAALNTLSQMKLDILTGICYSDNVLYDIWLLITSLGPNCGM 518
            .:.|.       |...||   |..:.:....|.:...| |....|..:|...:|.:..   :| :
Yeast   739 GIWSVLKKCIFHEDFDVS---GFEFTSTGLASSITKRI-TSSTVSHFILAKSFLEVFE---DC-I 795

  Fly   519 KEYLELLKSE-TNLQKPQTAMLMLFCDCMTH-------------------------------YVT 551
            ..:||:|:|. |.|:.      ....||..|                               ..|
Yeast   796 DRFLEILQSALTRLEN------FSIVDCGLHDGGGVSSLAKEIKIKLVYDGDASKDNIGTDLSST 854

  Fly   552 ILDEH--EMYTEQNPFKLNDYVLLTYFLNNILYKLINDNLLAG---AKNIVQH------------ 599
            |:..|  ..:|..|.| |...::...|||:::..|.:.:..|.   .:|.:.|
Yeast   855 IVSVHCIASFTSLNEF-LRHRMVRMRFLNSLIPNLTSSSTEADREEEENCLDHMRKKNFDFFYDN 918

  Fly   600 -------------------------PVFLSLHTLMLC------------------------LYRR 615
                                     .::...||:..|                        .|:
Yeast   919 EKVDMESTVFGVIFNTFVRRNRDLKTLWDDTHTIKFCKSLEGNNRESEAAEEANEGKKLRDFYK- 982

  Fly   616 DCRRPFTPPKHWLIPE------------VKPSTFINDLEKAKRN-----------------AMLL 651
              :|.|.........:            ||..:|||....||..                 ::.|
Yeast   983 --KREFAQVDTGSSADILTLLDFLHSCGVKSDSFINSKLSAKLARQLDEPLVVASGALPDWSLFL 1045

  Fly   652 LAKMPHIIPHEDR--------------VKLFR------KFVQNEKAVMGLTESACASPRSALIVI 696
            ..:.|.:.|.:.|              ::|::      |.::|::|:..|........|     |
Yeast  1046 TRRFPFLFPFDTRMLFLQCTSFGYGRLIQLWKNKSKGSKDLRNDEALQQLGRITRRKLR-----I 1105

  Fly   697 HRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLF 761
            .|..|...|.:.|:...:.  ..|:.:.:..:.|   .|:   |...||.....|.....|||::
Yeast  1106 SRKTIFATGLKILSKYGSS--PDVLEIEYQEEAG---TGL---GPTLEFYSVVSKYFARKSLNMW 1162

  Fly   762 K-------------TTSD---QRLYPSPISYVQDNH--LELFEFVGRMLGKAVYEGIVVDVPFAS 808
            :             ||.|   ..|:|.|::...:|.  :|||.::|..:.:::.:..::|..|:.
Yeast  1163 RCNSYSYRSEMDVDTTDDYITTLLFPEPLNPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSK 1227

  Fly   809 FFLSQL-------LGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQD---VSDLNLTFSV--DQ 861
            .|...|       :......:.:|:..:..:|..|.:||.:|...|.|   :..|:|||:|  :.
Yeast  1228 VFFELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFTVPGND 1292

  Fly   862 DVMGKIVTLALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFS 926
            |:       .|.|||..:.:|..|...|||.:....:...|.:|..||..||..:.:.|.:.:..
Yeast  1293 DI-------ELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILF 1350

  Fly   927 PPELQRLISGDTSPLDLKDLQKHTHYYGGF-------HDTHQVVCWLWDILAKDFTEEERKLFLK 984
            |.||..:.........:..|..:.:...|:       ||...::        ..|.:.||:|||:
Yeast  1351 PDELVDIFGRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFISII--------SAFGKHERRLFLQ 1407

  Fly   985 FVTSCSKPPLLGFAHLEPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNL 1049
            |:|...|.|:.||..|.|.|:: .::.::|..|.|                  ..||:..||.|.
Yeast  1408 FLTGSPKLPIGGFKSLNPKFTV-VLKHAEDGLTAD------------------EYLPSVMTCANY 1453

  Fly  1050 LKLPNYQKKSTLRDKLRYAVSSNTG-FELS 1078
            ||||.|..|..:|.:|..|:....| |.||
Yeast  1454 LKLPKYTSKDIMRSRLCQAIEEGAGAFLLS 1483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	100/419 (24%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	95/394 (24%)
UFD4	NP_012915.3	HUL4	581..1482	CDD:227354	180/965 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900